GENETICS OF RECEPTORS - MEDICATED ENDOCYTOSIS

受体遗传学 - 药物内吞作用

• 批准号: 7731330
• 负责人: MONTY KRIEGER
• 金额: $ 0.19万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731330
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Endocytosis; Funding; Genetic; Grant; HDL receptor; High Density Lipoproteins; Human; Institution; Lipoprotein Receptor; Lipoproteins; Low-Density Lipoproteins; Mediating; Plasma; Research; Research Personnel; Resources; Serum; Source; United States National Institutes of Health; lipid transport; receptor; receptor binding

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Study will isolate Lipoproteins from human plasma to study lipoprotein receptors, especially LDL and HDL. The precise mechanisms by which these receptors bind their liproproteins and mediate lipid transport are unknowns for the HDL receptor, and we will use liproprotein-deficient serum to study the mechanisms.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 研究将从人血浆中分离脂蛋白来研究脂蛋白受体，特别是低密度脂蛋白和高密度脂蛋白。对于 HDL 受体来说，这些受体结合脂蛋白并介导脂质转运的精确机制尚不清楚，我们将使用脂蛋白​​缺陷血清来研究其机制。