Time Course of Subthalamic Deep Brain Stimulation

丘脑深部脑刺激的时间进程

• 批准号: 7318516
• 负责人: SCOTT E COOPER
• 金额: $ 15.59万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7318516
• 关键词: Accounting; Animal Model; Basal Ganglia; Biophysics; Bradykinesia; Brain; Cell physiology; Clinical; Clinical Research; Computer Simulation; Deep Brain Stimulation; Dependence; EEF1A2 gene; Frequencies; Future; Goals; Half-Life; Implant; Intercept; K-Series Research Career Programs; Measures; Mentors; Modeling; Motor; Movement Disorders; Muscle Rigidity; Neurology; Neurons; Parkinson Disease; Parkinsonian Disorders; Patients; Physiological; Physiology; Protocols documentation; Range; Research; Research Personnel; Research Training; Series; Simulate; Structure of subthalamic nucleus; Symptoms; Synapses; Synaptic plasticity; Techniques; Testing; Therapeutic Effect; Time; Tissue Viability; Training; Tremor; design; improved; neurophysiology; novel; novel therapeutics; patient oriented; patient oriented research; programs; research study; success

DESCRIPTION (provided by applicant): This is an application for a K23 Mentored Patient-Oriented Career Development Award entitled "Time Course of Subthalamic Deep Brain Stimulation." The primary goal of the proposed research is to delineate new therapeutic mechanisms of action of Subthalamic nucleus deep brain stimulation (STN DBS). STN DBS is a highly effective, widely used treatment for Parkinson's disease (PD). Therapeutic effects of STN DBS persist for some time after stimulation ceases. Mechanisms of action of STN DBS, particularly of such "persistent" effects, are not well understood. Experiments are proposed in which STN DBS effects on PD symptoms are measured over time when STN DBS is turned on and off in patients with STN stimulators implanted for treatment of PD, to test the hypothesis that the mechanism of lingering effects differs from that of "immediate" effects seen during stimulation. Experiments are integrated with a computer simulation of neuronal biophysics to test the hypothesis that DBS-induced synaptic plasticity accounts for lingering effects. The candidate has clinical training in neurology/movement disorders, including PD and in DBS, including STN DBS for PD. He has research training in motor neurophysiology, in animal models. The goal of the proposed Career Development Award is to enable him to merge his clinical and research training in a program of patient-oriented research focusing on the use of brain stimulation to study movement disorders and improve their treatment, using computer modeling techniques to relate cellular processes to clinical observable therapeutic effects. To this end, the candidate seeks training in 1) basal ganglia physiology and biophysics of DBS, 2) computer modeling techniques 3) patient-oriented research.

描述（由申请人提供）：这是K23指导的以患者为导向的职业发展奖的申请，标题为“亚丘脑深脑刺激的时间课程”。拟议的研究的主要目标是描述丘脑核下深脑刺激（STN DBS）作用的新治疗机制。 STN DBS是帕金森氏病（PD）的高效，广泛使用的治疗方法。刺激停止后，STN DBS的治疗作用持续了一段时间。 STN DBS的作用机理，特别是这种“持续性”效应的作用机理，尚不清楚。提出了实验，其中在植入用于治疗PD的患者的患者中打开和关闭STN DBS的STN DBS随时间衡量了STN DBS对PD症状的影响，以检验以下假设：缠绕效应的机制与刺激过程中所见的“直接”效应的机制不同。实验与对神经元生物物理学的计算机模拟进行了整合，以测试DBS诱导的突触可塑性挥之不去的效果的假设。该候选人在包括PD和DBS（包括PD的STN DBS）中接受神经病/运动障碍的临床培训。他在动物模型中接受了运动神经生理学的研究培训。拟议的职业发展奖的目标是使他能够将其临床和研究培训合并为以患者为导向的研究计划，重点是使用脑刺激来研究运动障碍并改善其治疗方法，并使用计算机建模技术将细胞过程与临床可观察的治疗作用相关联。为此，候选人寻求在1）基底神经节生理学和DBS的生物物理学中进行培训，2）计算机建模技术3）面向患者的研究。