Time Course of Subthalamic Deep Brain Stimulation

丘脑深部脑刺激的时间进程

• 批准号: 7318516
• 负责人: SCOTT E COOPER
• 金额: $ 15.59万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7318516
• 关键词: Accounting; Animal Model; Basal Ganglia; Biophysics; Bradykinesia; Brain; Cell physiology; Clinical; Clinical Research; Computer Simulation; Deep Brain Stimulation; Dependence; EEF1A2 gene; Frequencies; Future; Goals; Half-Life; Implant; Intercept; K-Series Research Career Programs; Measures; Mentors; Modeling; Motor; Movement Disorders; Muscle Rigidity; Neurology; Neurons; Parkinson Disease; Parkinsonian Disorders; Patients; Physiological; Physiology; Protocols documentation; Range; Research; Research Personnel; Research Training; Series; Simulate; Structure of subthalamic nucleus; Symptoms; Synapses; Synaptic plasticity; Techniques; Testing; Therapeutic Effect; Time; Tissue Viability; Training; Tremor; design; improved; neurophysiology; novel; novel therapeutics; patient oriented; patient oriented research; programs; research study; success

DESCRIPTION (provided by applicant): This is an application for a K23 Mentored Patient-Oriented Career Development Award entitled "Time Course of Subthalamic Deep Brain Stimulation." The primary goal of the proposed research is to delineate new therapeutic mechanisms of action of Subthalamic nucleus deep brain stimulation (STN DBS). STN DBS is a highly effective, widely used treatment for Parkinson's disease (PD). Therapeutic effects of STN DBS persist for some time after stimulation ceases. Mechanisms of action of STN DBS, particularly of such "persistent" effects, are not well understood. Experiments are proposed in which STN DBS effects on PD symptoms are measured over time when STN DBS is turned on and off in patients with STN stimulators implanted for treatment of PD, to test the hypothesis that the mechanism of lingering effects differs from that of "immediate" effects seen during stimulation. Experiments are integrated with a computer simulation of neuronal biophysics to test the hypothesis that DBS-induced synaptic plasticity accounts for lingering effects. The candidate has clinical training in neurology/movement disorders, including PD and in DBS, including STN DBS for PD. He has research training in motor neurophysiology, in animal models. The goal of the proposed Career Development Award is to enable him to merge his clinical and research training in a program of patient-oriented research focusing on the use of brain stimulation to study movement disorders and improve their treatment, using computer modeling techniques to relate cellular processes to clinical observable therapeutic effects. To this end, the candidate seeks training in 1) basal ganglia physiology and biophysics of DBS, 2) computer modeling techniques 3) patient-oriented research.

描述（由申请人提供）：这是一份 K23 指导的以患者为导向的职业发展奖的申请，题为“丘脑深部脑刺激的时间进程”。拟议研究的主要目标是描绘丘脑底核深部脑刺激（STN DBS）作用的新治疗机制。 STN DBS 是一种高效、广泛使用的帕金森病 (PD) 治疗方法。 STN DBS 的治疗效果在刺激停止后仍会持续一段时间。 STN DBS 的作用机制，特别是这种“持久”效应，尚不清楚。提出了实验，在植入 STN 刺激器用于治疗 PD 的患者中打开和关闭 STN DBS 时，随着时间的推移测量 STN DBS 对 PD 症状的影响，以检验挥之不去的效应机制与刺激期间看到的“立即”效应不同的假设。实验与神经元生物物理学的计算机模拟相结合，以检验 DBS 诱导的突触可塑性解释挥之不去的影响的假设。候选人接受过神经学/运动障碍（包括 PD 和 DBS）方面的临床培训，包括针对 PD 的 STN DBS。他接受过运动神经生理学和动物模型方面的研究培训。拟议的职业发展奖的目标是使他能够将临床和研究培训合并到以患者为导向的研究计划中，重点是使用大脑刺激来研究运动障碍并改善其治疗，使用计算机建模技术将细胞过程与临床可观察到的治疗效果联系起来。为此，候选人寻求 1) 基底神经节生理学和 DBS 生物物理学的培训，2) 计算机建模技术 3) 以患者为导向的研究。