UMN Udall Clinical Core

明尼苏达大学（UMN）Udall中心临床核心将由Scott库珀博士，医学博士和Paul Tuite，MD.临床核心将招募100名帕金森病（PD）患者， 与项目1和2相关的人类受试者的脑深部电刺激（DBS）方案以及 催化剂项目。临床核心将收集术前基线和纵向运动和非运动 使用NINDS PD专用通用数据元素（CDE）以及DBS程控数据进行评估。 临床中心还将从入组受试者中收集基线生物样本，用于BioSEND储存库， 补充CDE，生物统计学核心将进入NINDS帕金森病生物标志物 程序数据管理资源。与罗切斯特大学尤德尔中心和Sage合作 生物识别，UMN临床核心将收集使用mPower 2.0智能手机应用程序的家庭评估， 项目2，将该应用程序扩展到一个新的DBS PD患者队列。临床中心将与 生物统计，行政和成像核心，以支持所有中心和项目的目标。

The University of Minnesota (UMN) Udall Center Clinical Core will be led by Scott Cooper PhD, MD and Paul Tuite, MD. The Clinical Core will recruit 100 patients with Parkinson's disease (PD) who are candidates for deep brain stimulation (DBS) for the human subjects protocols associated with Projects 1 and 2 and the Catalyst Project. The Clinical Core will collect pre-surgical baseline and longitudinal motor and non-motor assessments using NINDS PD-specific Common Data Elements (CDE) as well as DBS programming data. The Clinical Core will also collect baseline biosamples from enrolled participants for the BioSEND repository to supplement the CDE’s that Biostatistics Core will enter into the NINDS Parkinson’s Disease Biomarkers Program Data Management Resource. In collaboration with the University of Rochester Udall Center and Sage Biometrics, the UMN Clinical Core will collect in-home assessments using the mPower 2.0 smartphone app for Project 2, extending this app to a new cohort of PD patients with DBS. The Clinical Core will work closely with the Biostatistics, Administrative, and Imaging Core to support all Center and Project aims.