UMN Udall Clinical Core

明尼苏达大学(UMN)尤德尔中心临床核心将由斯科特·库珀博士、医学博士和保罗领导 马里兰州图伊特临床核心将招募100名帕金森氏病(PD)患者，他们是 与项目1和2相关的人类受试者的脑深部刺激(DBS)方案 催化剂项目。临床核心将收集手术前基线和纵向运动和非运动 使用NINDS PD专用公共数据元素(CDE)以及DBS编程数据进行评估。 临床核心还将从登记的参与者那里收集基线生物样本，供BioSEND存储库使用 补充CDE，生物统计学核心将进入NINDS帕金森病生物标记物 计划数据管理资源。与罗切斯特大学Udall中心和Sage合作 生物识别，UMN临床核心将使用mPower 2.0智能手机应用程序收集家庭评估 项目2，将这款应用程序扩展到患有DBS的PD患者的新队列。临床核心将与 支持所有中心和项目目标的生物统计、管理和成像核心。

The University of Minnesota (UMN) Udall Center Clinical Core will be led by Scott Cooper PhD, MD and Paul Tuite, MD. The Clinical Core will recruit 100 patients with Parkinson's disease (PD) who are candidates for deep brain stimulation (DBS) for the human subjects protocols associated with Projects 1 and 2 and the Catalyst Project. The Clinical Core will collect pre-surgical baseline and longitudinal motor and non-motor assessments using NINDS PD-specific Common Data Elements (CDE) as well as DBS programming data. The Clinical Core will also collect baseline biosamples from enrolled participants for the BioSEND repository to supplement the CDE’s that Biostatistics Core will enter into the NINDS Parkinson’s Disease Biomarkers Program Data Management Resource. In collaboration with the University of Rochester Udall Center and Sage Biometrics, the UMN Clinical Core will collect in-home assessments using the mPower 2.0 smartphone app for Project 2, extending this app to a new cohort of PD patients with DBS. The Clinical Core will work closely with the Biostatistics, Administrative, and Imaging Core to support all Center and Project aims.