Time Course of Subthalamic Deep Brain Stimulation
Time Course of Subthalamic Deep Brain Stimulation
批准号:
7682949
负责人:
SCOTT E COOPER
金额:
$16.37万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-09-01 至 2012-08-31
关键词:
AccountingAnimal ModelAttentionBasal GangliaBiophysicsBradykinesiaBrainCationsCell NucleusCell physiologyClinicalClinical ResearchComputer SimulationDeep Brain StimulationDependenceEpilepsyFrequenciesFutureGoalsHalf-LifeImplantInterceptK-Series Research Career ProgramsMeasuresMentorsMinkModelingMotorMovement DisordersMuscle RigidityNeurologyNeuronsOutputParkinson DiseaseParkinsonian DisordersPatientsPhysiologicalPhysiologyProtocols documentationResearchResearch PersonnelResearch TrainingSeriesSimulateStructure of subthalamic nucleusSymptomsSynapsesSynaptic plasticityTechniquesTestingThalamic NucleiTherapeutic EffectTimeTissue ViabilityTrainingTremorbasedepressiondesignimprovedneurophysiologynovelnovel therapeuticspatient orientedpatient oriented researchprogramsrelating to nervous systemresearch studysuccesstheories
中文摘要
这是申请 K-23 指导的以患者为导向的职业发展奖,题为“时间”
丘脑深部脑刺激过程。”拟议研究的主要目标是描绘
丘脑底核深部脑刺激(STN DBS)的新治疗作用机制。星展银行
是一种高效、广泛使用的帕金森病 (PD) 治疗方法。 STN DBS 的治疗效果
刺激停止后仍会持续一段时间。 STN DBS 的作用机制,特别是此类
“持久”效应尚未得到很好的理解。
提出了实验,其中当 STN 时,随着时间的推移测量 STN DBS 对 PD 症状的影响。
在植入 STN 刺激器治疗 PD 的患者中打开和关闭 DBS,以测试
假设挥之不去的影响机制与“直接”影响的机制不同
刺激。实验与神经元生物物理学的计算机模拟相结合,以测试
DBS 诱导的突触可塑性是造成挥之不去的影响的假设。
候选人接受过神经学/运动障碍方面的临床培训,包括 PD 和 DBS,包括
用于 PD 的 STN DBS。他接受过运动神经生理学和动物模型方面的研究培训。的目标
拟议的职业发展奖旨在使他能够将临床和研究培训结合起来
以患者为中心的研究计划,重点是利用大脑刺激来研究运动障碍
并改进他们的治疗,使用计算机建模技术将细胞过程与临床联系起来
可观察到的治疗效果。为此,候选人寻求以下方面的培训:1) 基底神经节生理学和
DBS 的生物物理学,2)计算机建模技术3)以患者为导向的研究。
英文摘要
This is an application for a K-23 Mentored Patient Oriented Career Development award entitled "Time
Course of Subthalamic Deep Brain Stimulation." The primary goal of the proposed research is to delineate
new therapeutic mechanisms of action of Subthalamic nucleus deep brain stimulation (STN DBS). STN DBS
is a highly effective, widely used treatment for Parkinson's disease (PD). Therapeutic effects of STN DBS
persist for some time after stimulation ceases. Mechanisms of action of STN DBS, particularly of such
"persistent" effects, are not well understood.
Experiments are proposed in which STN DBS effects on PD symptoms are measured over time when STN
DBS is turned on and off in patients with STN stimulators implanted for treatment of PD, to test the
hypothesis that the mechanism of lingering effects differs from that of "immediate" effects seen during
stimulation. Experiments are integrated with a computer simulation of neuronal biophysics to test the
hypothesis that DBS-induced synaptic plasticity accounts for lingering effects.
The candidate has clinical training in neurology/movement disorders, including PD and in DBS, including
STN DBS for PD. He has research training in motor neurophysiology, in animal models. The goal of the
proposed Career Development Award is to enable him to merge his clinical and research training in a
program of patient oriented research focusing on the use of brain stimulation to study movement disorders
and improve their treatment, using computer modeling techniques to relate cellular processes to clinical
observable therapeutic effects. To this end, the candidate seeks training in 1) basal ganglia physiology and
biophysics of DBS, 2) computer modeling techniques 3) patient oriented research.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Targeted Pathway Activation for PosturalInstability and Gait Disorder in Parkinson'sDisease
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批准号:10666621
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项目类别:
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资助金额:$74.55万
-
财政年份:2022
-
负责人:SCOTT E COOPER
-
依托单位:
UMN Udall Clinical Core
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批准号:10703243
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项目类别:
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资助金额:$41.24万
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财政年份:2021
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负责人:SCOTT E COOPER
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依托单位:
UMN Udall Clinical Core
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批准号:10282961
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项目类别:
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资助金额:$42.4万
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财政年份:2021
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负责人:SCOTT E COOPER
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依托单位:
UMN Udall Clinical Core
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批准号:10489830
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项目类别:
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资助金额:$41.13万
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财政年份:2021
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负责人:SCOTT E COOPER
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依托单位:
Time Course of Subthalamic Deep Brain Stimulation
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批准号:8142844
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项目类别:
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资助金额:$16.75万
-
财政年份:2007
-
负责人:SCOTT E COOPER
-
依托单位:
Time Course of Subthalamic Deep Brain Stimulation
-
批准号:7446160
-
项目类别:
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资助金额:$16.26万
-
财政年份:2007
-
负责人:SCOTT E COOPER
-
依托单位:
Time Course of Subthalamic Deep Brain Stimulation
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批准号:7318516
-
项目类别:
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资助金额:$15.59万
-
财政年份:2007
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负责人:SCOTT E COOPER
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依托单位:
Time Course of Subthalamic Deep Brain Stimulation
-
批准号:7914105
-
项目类别:
-
资助金额:$16.4万
-
财政年份:2007
-
负责人:SCOTT E COOPER
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依托单位:
海外基金