Time Course of Subthalamic Deep Brain Stimulation

丘脑深部脑刺激的时间进程

基本信息

批准号：
7914105
负责人：
SCOTT E COOPER
金额：
$ 16.4万
依托单位：
CLEVELAND CLINIC LERNER COM-CWRU
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7914105
关键词：
Accounting Animal Model Attention Basal Ganglia Biophysics Bradykinesia Brain Cations Cell Nucleus Cell physiology Clinical Clinical Research Computer Simulation Deep Brain Stimulation Dependence Epilepsy Frequencies Future Goals Half-Life Implant Intercept K-Series Research Career Programs Measures Mental Depression Mentors Mink Modeling Motor Movement Disorders Muscle Rigidity Neurology Neurons Output Parkinson Disease Parkinsonian Disorders Patients Physiological Physiology Protocols documentation Research Research Personnel Research Training Series Simulate Structure of subthalamic nucleus Symptoms Synapses Synaptic plasticity Techniques Testing Thalamic Nuclei Therapeutic Effect Time Tissue Viability Training Tremor base design improved neurophysiology novel novel therapeutics patient oriented patient oriented research programs relating to nervous system research study success theories

项目摘要

This is an application for a K-23 Mentored Patient Oriented Career Development award entitled "Time Course of Subthalamic Deep Brain Stimulation." The primary goal of the proposed research is to delineate new therapeutic mechanisms of action of Subthalamic nucleus deep brain stimulation (STN DBS). STN DBS is a highly effective, widely used treatment for Parkinson's disease (PD). Therapeutic effects of STN DBS persist for some time after stimulation ceases. Mechanisms of action of STN DBS, particularly of such "persistent" effects, are not well understood. Experiments are proposed in which STN DBS effects on PD symptoms are measured over time when STN DBS is turned on and off in patients with STN stimulators implanted for treatment of PD, to test the hypothesis that the mechanism of lingering effects differs from that of "immediate" effects seen during stimulation. Experiments are integrated with a computer simulation of neuronal biophysics to test the hypothesis that DBS-induced synaptic plasticity accounts for lingering effects. The candidate has clinical training in neurology/movement disorders, including PD and in DBS, including STN DBS for PD. He has research training in motor neurophysiology, in animal models. The goal of the proposed Career Development Award is to enable him to merge his clinical and research training in a program of patient oriented research focusing on the use of brain stimulation to study movement disorders and improve their treatment, using computer modeling techniques to relate cellular processes to clinical observable therapeutic effects. To this end, the candidate seeks training in 1) basal ganglia physiology and biophysics of DBS, 2) computer modeling techniques 3) patient oriented research.

这是K-23指导的以患者为导向的职业发展奖的申请，标题为“时间丘脑下深脑刺激的过程。”拟议研究的主要目标是描述丘脑下核深脑刺激（STN DBS）作用的新治疗机制。 STN DBS 是帕金森氏病（PD）的高效，广泛使用的治疗方法。 STN DBS的治疗作用刺激停止后持续一段时间。 STN DBS的作用机制，特别是 “持续”效果并不理解。提出了实验，其中STN DBS对PD症状的影响会随着时间的推移测量植入用于治疗PD的患者的患者中，DBS打开和关闭，以测试假设挥之不去效应的机制与在刺激。实验与神经元生物物理学的计算机模拟进行了整合，以测试 DBS诱导的突触可塑性的假设是挥之不去的效果。该候选人在神经/运动障碍中接受了包括PD和DBS的临床培训，包括 PD的STN DB。他在动物模型中接受了运动神经生理学的研究培训。目标的目标拟议的职业发展奖是为了使他能够合并他的临床和研究培训针对患者的研究计划，重点是使用大脑刺激研究运动障碍并使用计算机建模技术将细胞过程与临床相关联，并改善其处理可观察的治疗作用。为此，候选人在1）基底神经节生理学和 DBS的生物物理学，2）计算机建模技术3）面向患者的研究。