Point of Care Superconducting MRI Diagnostic Tool

护理点超导 MRI 诊断工具

• 批准号: 7327276
• 负责人: Michael J Tomsic
• 金额: $ 9.69万
• 依托单位: HYPER TECH RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7327276
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DESCRIPTION (provided by applicant): In an effort to meet the current and projected needs for increased reliance on magnetic resonance imaging (MRI) in clinical diagnoses, this Phase I - Phase II Fast Track proposal addresses the specific aim of providing an open-access, low-field, high- resolution imaging system targeted for physicians' offices, small clinics and imaging centers. Building on recent developments of magnesium diboride (MgB2) superconductor wire by Hyper Tech, the recent advances in high temperature superconductor RF receiver coils and lower cost pulsed-tube cryocoolers, an enhanced point-of-care MRI imaging system can be developed for an examination room type environment, thereby enabling a much larger number of patient conditions to be scheduled at MRI imaging centers without the need for building large shielded rooms and while freeing up the large magnet units for more complex studies. By using a superconducting magnet and high temperature superconducting RF coils for improved signal-to-noise-ratio (SNR), a dc magnet can be developed that will significantly expand the imaging capability of the current MagneVu permanent magnet (PM) based MRI while maintaining a low-cost alternative for select medical conditions, which are now dependent on the large magnet imaging at much higher capital and operating costs. Building on the model of an open- access geometry and an inhomogeneous magnetic field, the envisaged MRI system will be developed in three phases. Phase I will address the overall feasibility issues and delineate the specific requirements for the MgB2 based superconducting magnet using the technical experience gained from the existing PM based MagneVu system. A conceptual and preliminary design for the envisaged MRI will result. In Phase II, the magnet detail design will be completed and magnet and ancillary systems fabricated or procured. In parallel, the balance of the imaging system will be designed and/or modified from existing hardware and software and procured as necessary. At the end of Phase II, a completed prototype system will be available for preliminary tests. The proposed research will enable patients to be seen and diagnosed at point-of-care in local doctors' offices and clinics in a timelier manner This will enable earlier diagnosis of medical conditions so that treatment can begin sooner and be monitored more closely than currently possible. Lower cost imaging equipment will translate into increased usage and wider availability, thus better patient care at a lower cost.

描述(由申请人提供)：为了满足临床诊断中对磁共振成像(MRI)日益依赖的当前和预期需求，这项第一阶段-第二阶段快速跟踪提案针对的具体目标是提供一种针对医生办公室、小型诊所和成像中心的开放接入、低场强、高分辨率成像系统。基于Hyper Tech对二硼化镁(MgB2)超导线的最新开发，高温超导射频接收器线圈和低成本脉冲管制冷器的最新进展，可以为检查室类型的环境开发增强型护理点MRI成像系统，从而使MRI成像中心能够在不需要建造大型屏蔽室的情况下安排更多的患者病情，同时释放大型磁体单元用于更复杂的研究。通过使用超导磁体和高温超导射频线圈来提高信噪比(SNR)，可以开发出一种直流磁体，它将显著扩展当前基于MagneVu永久磁体(PM)的MRI的成像能力，同时为特定的医疗条件保持低成本的替代方案，这些条件现在依赖于资本和运营成本高得多的大磁体成像。在开放式几何结构和不均匀磁场模型的基础上，设想的磁共振成像系统将分三个阶段开发。第一阶段将解决总体可行性问题，并利用从现有的以粉末冶金为基础的MagneVu系统获得的技术经验，描述对以镁为基础的超导磁体的具体要求。将产生设想的核磁共振成像的概念性和初步设计。在第二阶段，将完成磁铁的详细设计，并制造或采购磁铁和辅助系统。同时，成像系统的其余部分将根据现有硬件和软件进行设计和/或修改，并在必要时采购。在第二阶段结束时，一个完整的原型系统将可用于初步测试。拟议的研究将使患者能够更及时地在当地医生办公室和诊所的医疗点就诊和诊断，这将使更早地诊断医疗状况，从而能够比目前更早地开始治疗并更密切地监测治疗。低成本的成像设备将转化为更高的使用率和更广泛的可获得性，从而以更低的成本提供更好的患者护理。