Point of Care Superconducting MRI Diagnostic Tool

护理点超导 MRI 诊断工具

• 批准号: 7327276
• 负责人: Michael J Tomsic
• 金额: $ 9.69万
• 依托单位: HYPER TECH RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7327276
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DESCRIPTION (provided by applicant): In an effort to meet the current and projected needs for increased reliance on magnetic resonance imaging (MRI) in clinical diagnoses, this Phase I - Phase II Fast Track proposal addresses the specific aim of providing an open-access, low-field, high- resolution imaging system targeted for physicians' offices, small clinics and imaging centers. Building on recent developments of magnesium diboride (MgB2) superconductor wire by Hyper Tech, the recent advances in high temperature superconductor RF receiver coils and lower cost pulsed-tube cryocoolers, an enhanced point-of-care MRI imaging system can be developed for an examination room type environment, thereby enabling a much larger number of patient conditions to be scheduled at MRI imaging centers without the need for building large shielded rooms and while freeing up the large magnet units for more complex studies. By using a superconducting magnet and high temperature superconducting RF coils for improved signal-to-noise-ratio (SNR), a dc magnet can be developed that will significantly expand the imaging capability of the current MagneVu permanent magnet (PM) based MRI while maintaining a low-cost alternative for select medical conditions, which are now dependent on the large magnet imaging at much higher capital and operating costs. Building on the model of an open- access geometry and an inhomogeneous magnetic field, the envisaged MRI system will be developed in three phases. Phase I will address the overall feasibility issues and delineate the specific requirements for the MgB2 based superconducting magnet using the technical experience gained from the existing PM based MagneVu system. A conceptual and preliminary design for the envisaged MRI will result. In Phase II, the magnet detail design will be completed and magnet and ancillary systems fabricated or procured. In parallel, the balance of the imaging system will be designed and/or modified from existing hardware and software and procured as necessary. At the end of Phase II, a completed prototype system will be available for preliminary tests. The proposed research will enable patients to be seen and diagnosed at point-of-care in local doctors' offices and clinics in a timelier manner This will enable earlier diagnosis of medical conditions so that treatment can begin sooner and be monitored more closely than currently possible. Lower cost imaging equipment will translate into increased usage and wider availability, thus better patient care at a lower cost.

描述（由申请人提供）：为了满足临床诊断中对磁共振成像（MRI）日益依赖的当前和预计需求，本I - II期快速通道提案旨在为医生办公室、小型诊所和成像中心提供开放获取、低场、高分辨率成像系统的具体目标。基于Hyper Tech公司最新开发的二硼化镁（MgB2）超导线，高温超导射频接收器线圈和低成本脉冲管冷冻器的最新进展，可以开发用于检查室型环境的增强点护理MRI成像系统。这样就可以在MRI成像中心安排更多的患者情况，而不需要建造大型屏蔽室，同时腾出大型磁铁单元用于更复杂的研究。通过使用超导磁体和高温超导射频线圈来提高信噪比（SNR），可以开发出直流磁体，这将大大扩展当前基于MagneVu永磁体（PM）的MRI的成像能力，同时在某些医疗条件下保持低成本的替代方案，这些条件现在依赖于高得多的资金和运营成本的大型磁体成像。基于开放的几何结构和非均匀磁场模型，设想的MRI系统将分三个阶段开发。第一阶段将解决总体可行性问题，并利用从现有的基于PM的MagneVu系统中获得的技术经验，描述基于MgB2的超导磁体的具体要求。将对设想的MRI进行概念性和初步设计。在第二阶段，将完成磁体的详细设计，并制造或采购磁体和辅助系统。同时，将根据现有的硬件和软件设计和/或修改成像系统的平衡，并视需要采购。在第二阶段结束时，一个完整的原型系统将可用于初步测试。拟议的研究将使病人能够更及时地在当地医生办公室和诊所的护理点被看到和诊断，从而能够更早地诊断病情，以便比目前更早地开始治疗和更密切地监测。更低成本的成像设备将转化为更多的使用和更广泛的可用性，从而以更低的成本提供更好的患者护理。