MRI Image Guided Radiation Therapy (IGRT) system with low cost, highly stable mag
MRI 图像引导放射治疗 (IGRT) 系统具有低成本、高度稳定的磁体
基本信息
- 批准号:8322707
- 负责人:
- 金额:$ 72.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-27 至 2014-08-31
- 项目状态:已结题
- 来源:
- 关键词:AbdomenAreaBathingCancerousClinicalCollaborationsComputer softwareCost AnalysisCost SavingsDevelopmentDoseDuct (organ) structureEngineeringEquipment and supply inventoriesGamma RaysHeliumImageIndustryJointsLeadLengthLettersLiquid substanceLocationMagnetic Resonance ImagingMagnetismMaintenanceMalignant NeoplasmsManufacturer NameModelingMovementNatural GasNiobiumOrganPerformancePhasePower SourcesPriceProceduresProgram DevelopmentPropertyRadiation therapyRenaissanceReportingResearchSeriesShippingShipsSideSmall Business Innovation Research GrantSourceStructureSystemTechniquesTechnologyTemperatureTestingTimeTitaniaTitaniumVacuumValidationWorkbasecancer therapycold temperaturecomparativecostcost effectivecryogenicscryostatdensitydesigndesign and constructionexhaustexpectationexperiencemagnesium boride (MgB2)magnetic fieldmeetingsmetermodel designoperationpressureprogramspublic health relevanceresearch and developmentruptured diskthermal stresstumor
项目摘要
DESCRIPTION (provided by applicant): Progress toward full development of ViewRay's Renaissance" System 1000 MRI image guided radiation therapy (IGRT) system is being threatened by the growing shortage of helium worldwide. This pioneering technology is aimed at treating cancerous tumors in the abdomen where bodily functions cause significant organ displacements making precise dose delivery difficult or impossible. Liquid helium is presently essential for operation of present day low temperature niobium-titanium (NbTi) based superconductor magnets. Helium worldwide is being depleted at a rate exceeding the capacity of the current natural gas wells (helium is a byproduct of some natural gas wells) around the world. The US strategic reserves are being sold off to stabilize the price but to little avail; the price of helium continues to rise. Projections from a variety of sources all point to major shortages and the price increases in the 2010-2015 time frame and beyond. This will threaten all helium users but most of all the MRI industry. Already, the three major MRI manufacturers, have development programs aimed at converting from re-condensing liquid helium bath cooling to dry conduction cooling to cryocoolers using magnesium diboride (MgB2) superconductors. Hyper Tech has active programs with all three to utilize magnesium diboride (MgB2) superconductors. Magnesium diboride superconductors have the unique property of being superconducting a full 30 K higher than the currently used niobium titanium (NbTi) while being in the same wire form suitable for large magnet manufacturing. MgB2 enables converting from the liquid helium bath cooling to conduction cooling because of this wide temperature margin needed to accommodate temperature gradients in the magnet. Even without the urgency brought on by the helium shortage, it is cost effective to all MRI manufacturers to transition their background magnets from liquid helium bath cooling to dry conduction cooling. With an inventory of ~2000 liters of liquid helium in a standard NbTi based MRI magnet, there is the ever present danger of a quench and sudden release of gaseous helium. A rupture disc and large exhaust duct to the outside are required for all present MRI installations. In addition, the dewar and vacuum enclosure must be ASME pressure vessel certified in case of an over pressure due to a failed rupture disc. These factors make a significant cost impact on the initial price of an MRI and the follow-on maintenance. This Phase I, Phase II Fast Track SBIR endeavors to remove the helium shortage obstacle facing ViewRay's development while at the same time providing an avenue to significantly lower the unit cost of their commercialized Renaissance" System 1000. During this program Hyper Tech will perform the necessary research in order to develop and fabricate a helium free background magnet system using its MgB2 superconductor wire. We will supply the magnet system to ViewRay who will incorporate it into their Renaissance" System 1000 MRI IGRT system and perform imaging tests to verify the overall magnet system performance compared with the present NbTi superconducting magnet based imaging system. This will lead to clinical validation of the fully integrated IGRT with Hyper Tech's MgB2 based background magnet system.
PUBLIC HEALTH RELEVANCE: The first true, real time MRI image guided radiation therapy (IGRT) system that delivers gamma radiation to malignant tumors with pinpoint accuracy in spite of organ movement will be demonstrated by ViewRay Renaissance" System 1000 using Hyper Tech's magnesium diboride superconducting magnets. The Hyper Tech MgB2 magnet system will significantly lower the cost and on-going maintenance costs of ViewRay's cancer treatment technology. In addition, the magnet system will be safer and less prone to quenching than presently used magnet system.
描述(由申请人提供):ViewRay的Renaissance System 1000 MRI图像引导放射治疗(IGRT)系统的全面开发进展正受到全球氦气日益短缺的威胁。这项开创性的技术旨在治疗腹部的癌性肿瘤,其中身体功能导致显著的器官移位,使得精确的剂量输送困难或不可能。液氦是目前低温铌-钛(NbTi)基超导体磁体运行所必需的。全球范围内的氦正在以超过当前全球天然气威尔斯井容量的速度耗尽(氦是一些天然气威尔斯井的副产品)。美国正在出售战略储备以稳定价格,但收效甚微;氦的价格继续上涨。各种来源的预测都表明,2010-2015年期间及以后将出现严重短缺和价格上涨。这将威胁到所有氦气用户,但最重要的是MRI行业。三大MRI制造商已经制定了开发计划,旨在将再冷凝液氦浴冷却转换为干传导冷却,再转换为使用二硼化镁(MgB 2)超导体的低温冷却器。Hyper Tech与这三家公司都有积极的计划,以利用二硼化镁(MgB 2)超导体。二硼化镁超导体具有比目前使用的铌钛(NbTi)高整整30 K的超导性的独特性质,同时具有适合于大型磁体制造的相同线材形式。MgB 2使得能够从液氦浴冷却转换为传导冷却,因为需要这种宽的温度裕度来适应磁体中的温度梯度。即使没有氦气短缺带来的紧迫性,对所有MRI制造商来说,将其背景磁体从液氦浴冷却过渡到干传导冷却也是具有成本效益的。在标准的基于NbTi的MRI磁体中具有~2000升的液态氦的库存的情况下,存在气态氦的骤冷和突然释放的始终存在的危险。所有现有的MRI装置都需要一个破裂盘和通向外部的大排气管。此外,杜瓦瓶和真空外壳必须通过ASME压力容器认证,以防破裂盘失效导致过压。这些因素对MRI的初始价格和后续维护产生了重大的成本影响。这个第一阶段,第二阶段快速轨道SBIR努力消除氦气短缺面临的障碍,同时提供了一个途径,以显着降低单位成本的商业化文艺复兴”系统1000。在该计划中,Hyper Tech将进行必要的研究,以便使用其MgB 2超导导线开发和制造无氦背景磁体系统。我们将向ViewRay提供磁体系统,ViewRay将其纳入其Renaissance”System 1000 MRI IGRT系统,并进行成像测试,以验证磁体系统的整体性能,并与目前基于NbTi超导磁体的成像系统进行比较。这将导致与Hyper Tech的基于MgB 2的背景磁体系统完全集成的IGRT的临床验证。
公共卫生相关性:第一个真正的,真实的时间MRI图像引导放射治疗(IGRT)系统,提供伽马辐射的恶性肿瘤与精确的精度,尽管器官的运动将被证明是ViewRay文艺复兴”系统1000使用超技术的二硼化镁超导磁体。Hyper Tech MgB 2磁体系统将显著降低ViewRay癌症治疗技术的成本和持续维护成本。此外,该磁体系统将比目前使用的磁体系统更安全并且更不易于失超。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Michael J Tomsic其他文献
Michael J Tomsic的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Michael J Tomsic', 18)}}的其他基金
Helium Free MRI Image Guided Radiation Therapy (IGRT) System for ViewRay Inc
适用于 ViewRay Inc 的无氦 MRI 图像引导放射治疗 (IGRT) 系统
- 批准号:
8932663 - 财政年份:2010
- 资助金额:
$ 72.79万 - 项目类别:
MRI Image Guided Radiation Therapy (IGRT) system with low cost, highly stable mag
MRI 图像引导放射治疗 (IGRT) 系统具有低成本、高度稳定的磁体
- 批准号:
8298310 - 财政年份:2010
- 资助金额:
$ 72.79万 - 项目类别:
MRI Image Guided Radiation Therapy (IGRT) system with low cost, highly stable mag
MRI 图像引导放射治疗 (IGRT) 系统具有低成本、高度稳定的磁体
- 批准号:
7803057 - 财政年份:2010
- 资助金额:
$ 72.79万 - 项目类别:
MRI Image Guided Radiation Therapy (IGRT) system with low cost, highly stable mag
MRI 图像引导放射治疗 (IGRT) 系统具有低成本、高度稳定的磁体
- 批准号:
8528376 - 财政年份:2010
- 资助金额:
$ 72.79万 - 项目类别:
Helium Free MRI Image Guided Radiation Therapy (IGRT) System for ViewRay Inc
适用于 ViewRay Inc 的无氦 MRI 图像引导放射治疗 (IGRT) 系统
- 批准号:
8840748 - 财政年份:2010
- 资助金额:
$ 72.79万 - 项目类别:
Accelerate improvements in MgB2 superconductor wire for new cryogen-free low cost
加速 MgB2 超导线材的改进,实现新型无制冷剂低成本
- 批准号:
7925211 - 财政年份:2010
- 资助金额:
$ 72.79万 - 项目类别:
Point of Care Superconducting MRI Diagnostic Tool
护理点超导 MRI 诊断工具
- 批准号:
7327276 - 财政年份:2007
- 资助金额:
$ 72.79万 - 项目类别:
Low Cost Magnesium Diboride Superconducting Wire for 7 to 10 Tesla MRI Systems
用于 7 至 10 特斯拉 MRI 系统的低成本二硼化镁超导线
- 批准号:
7357472 - 财政年份:2006
- 资助金额:
$ 72.79万 - 项目类别:
Low Cost Magnesium Diboride Superconducting Wire for 7 to 10 Tesla MRI Systems
用于 7 至 10 特斯拉 MRI 系统的低成本二硼化镁超导线
- 批准号:
7281013 - 财政年份:2006
- 资助金额:
$ 72.79万 - 项目类别:
Low Cost Magnesium Diboride Superconducting Wire for 7 to 10 Tesla MRI Systems
用于 7 至 10 特斯拉 MRI 系统的低成本二硼化镁超导线
- 批准号:
7156251 - 财政年份:2006
- 资助金额:
$ 72.79万 - 项目类别:
相似国自然基金
层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
- 批准号:2021JJ40433
- 批准年份:2021
- 资助金额:0.0 万元
- 项目类别:省市级项目
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
- 批准号:32001603
- 批准年份:2020
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
AREA国际经济模型的移植.改进和应用
- 批准号:18870435
- 批准年份:1988
- 资助金额:2.0 万元
- 项目类别:面上项目
相似海外基金
Onboarding Rural Area Mathematics and Physical Science Scholars
农村地区数学和物理科学学者的入职
- 批准号:
2322614 - 财政年份:2024
- 资助金额:
$ 72.79万 - 项目类别:
Standard Grant
TRACK-UK: Synthesized Census and Small Area Statistics for Transport and Energy
TRACK-UK:交通和能源综合人口普查和小区域统计
- 批准号:
ES/Z50290X/1 - 财政年份:2024
- 资助金额:
$ 72.79万 - 项目类别:
Research Grant
Wide-area low-cost sustainable ocean temperature and velocity structure extraction using distributed fibre optic sensing within legacy seafloor cables
使用传统海底电缆中的分布式光纤传感进行广域低成本可持续海洋温度和速度结构提取
- 批准号:
NE/Y003365/1 - 财政年份:2024
- 资助金额:
$ 72.79万 - 项目类别:
Research Grant
Point-scanning confocal with area detector
点扫描共焦与区域检测器
- 批准号:
534092360 - 财政年份:2024
- 资助金额:
$ 72.79万 - 项目类别:
Major Research Instrumentation
Collaborative Research: Scalable Manufacturing of Large-Area Thin Films of Metal-Organic Frameworks for Separations Applications
合作研究:用于分离应用的大面积金属有机框架薄膜的可扩展制造
- 批准号:
2326714 - 财政年份:2024
- 资助金额:
$ 72.79万 - 项目类别:
Standard Grant
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427233 - 财政年份:2024
- 资助金额:
$ 72.79万 - 项目类别:
Standard Grant
Collaborative Research: Scalable Manufacturing of Large-Area Thin Films of Metal-Organic Frameworks for Separations Applications
合作研究:用于分离应用的大面积金属有机框架薄膜的可扩展制造
- 批准号:
2326713 - 财政年份:2024
- 资助金额:
$ 72.79万 - 项目类别:
Standard Grant
Unlicensed Low-Power Wide Area Networks for Location-based Services
用于基于位置的服务的免许可低功耗广域网
- 批准号:
24K20765 - 财政年份:2024
- 资助金额:
$ 72.79万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427232 - 财政年份:2024
- 资助金额:
$ 72.79万 - 项目类别:
Standard Grant
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427231 - 财政年份:2024
- 资助金额:
$ 72.79万 - 项目类别:
Standard Grant