MRI Image Guided Radiation Therapy (IGRT) system with low cost, highly stable mag

MRI 图像引导放射治疗 (IGRT) 系统具有低成本、高度稳定的磁体

• 批准号: 8528376
• 负责人: Michael J Tomsic
• 金额: $ 63.65万
• 依托单位: HYPER TECH RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-27 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528376
• 关键词: Abdomen; Area; Bathing; Cancerous; Clinical; Collaborations; Computer software; Cost Analysis; Cost Savings; Development; Dose; Duct (organ) structure; Engineering; Equipment and supply inventories; Gamma Rays; Helium; Image; Industry; Joints; Lead; Length; Letters; Liquid substance; Location; Magnetic Resonance Imaging; Magnetism; Maintenance; Malignant Neoplasms; Manufacturer Name; Modeling; Movement; Natural Gas; Niobium; Organ; Performance; Phase; Power Sources; Price; Procedures; Program Development; Property; Renaissance; Reporting; Research; Series; Shipping; Ships; Side; Small Business Innovation Research Grant; Source; Structure; System; Techniques; Technology; Temperature; Testing; Time; Titania; Titanium; Vacuum; Validation; Work; base; cancer therapy; cold temperature; comparative; cost; cost effective; cryogenics; cryostat; density; design; design and construction; exhaust; expectation; experience; image guided radiation therapy; magnesium boride (MgB2); magnetic field; meetings; meter; model design; operation; pressure; programs; public health relevance; research and development; ruptured disk; thermal stress; tumor

DESCRIPTION (provided by applicant): Progress toward full development of ViewRay's Renaissance" System 1000 MRI image guided radiation therapy (IGRT) system is being threatened by the growing shortage of helium worldwide. This pioneering technology is aimed at treating cancerous tumors in the abdomen where bodily functions cause significant organ displacements making precise dose delivery difficult or impossible. Liquid helium is presently essential for operation of present day low temperature niobium-titanium (NbTi) based superconductor magnets. Helium worldwide is being depleted at a rate exceeding the capacity of the current natural gas wells (helium is a byproduct of some natural gas wells) around the world. The US strategic reserves are being sold off to stabilize the price but to little avail; the price of helium continues to rise. Projections from a variety of sources all point to major shortages and the price increases in the 2010-2015 time frame and beyond. This will threaten all helium users but most of all the MRI industry. Already, the three major MRI manufacturers, have development programs aimed at converting from re-condensing liquid helium bath cooling to dry conduction cooling to cryocoolers using magnesium diboride (MgB2) superconductors. Hyper Tech has active programs with all three to utilize magnesium diboride (MgB2) superconductors. Magnesium diboride superconductors have the unique property of being superconducting a full 30 K higher than the currently used niobium titanium (NbTi) while being in the same wire form suitable for large magnet manufacturing. MgB2 enables converting from the liquid helium bath cooling to conduction cooling because of this wide temperature margin needed to accommodate temperature gradients in the magnet. Even without the urgency brought on by the helium shortage, it is cost effective to all MRI manufacturers to transition their background magnets from liquid helium bath cooling to dry conduction cooling. With an inventory of ~2000 liters of liquid helium in a standard NbTi based MRI magnet, there is the ever present danger of a quench and sudden release of gaseous helium. A rupture disc and large exhaust duct to the outside are required for all present MRI installations. In addition, the dewar and vacuum enclosure must be ASME pressure vessel certified in case of an over pressure due to a failed rupture disc. These factors make a significant cost impact on the initial price of an MRI and the follow-on maintenance. This Phase I, Phase II Fast Track SBIR endeavors to remove the helium shortage obstacle facing ViewRay's development while at the same time providing an avenue to significantly lower the unit cost of their commercialized Renaissance" System 1000. During this program Hyper Tech will perform the necessary research in order to develop and fabricate a helium free background magnet system using its MgB2 superconductor wire. We will supply the magnet system to ViewRay who will incorporate it into their Renaissance" System 1000 MRI IGRT system and perform imaging tests to verify the overall magnet system performance compared with the present NbTi superconducting magnet based imaging system. This will lead to clinical validation of the fully integrated IGRT with Hyper Tech's MgB2 based background magnet system. PUBLIC HEALTH RELEVANCE: The first true, real time MRI image guided radiation therapy (IGRT) system that delivers gamma radiation to malignant tumors with pinpoint accuracy in spite of organ movement will be demonstrated by ViewRay Renaissance" System 1000 using Hyper Tech's magnesium diboride superconducting magnets. The Hyper Tech MgB2 magnet system will significantly lower the cost and on-going maintenance costs of ViewRay's cancer treatment technology. In addition, the magnet system will be safer and less prone to quenching than presently used magnet system.

描述（由申请人提供）：朝着ViewRay文艺复兴的全面发展的进展：“系统1000 MRI图像引导放射治疗（IGRT）系统受到全世界在全球氦气的日益短缺的威胁。这项开拓性技术旨在治疗腹部癌症的癌症在身体中的治疗，从而导致精确的供应剂量的固定剂量，从而使精确的供应剂量供应。尼鸟（NBTI）的氦气（NBTI）的氦气以超过当前天然气井的容量（氦气的副产品），这是全球范围内销售的速度。在2010-2015的时间范围内，这将威胁到所有氦气使用者，但大多数MRI行业，三个主要的MRI制造商。超导体。短缺，所有MRI制造商在液体氦气浴冷却中将其背景磁铁过渡到干燥的传导冷却，并在标准的基于NBTI的MRI磁铁中库存量为2000升液体氦气。由于破裂盘的失败，围栏必须是ASME压力容器，这些因素会对MRI的初始价格产生重大的成本影响，并在此阶段I阶段，II阶段的快速轨道SBIR努力下降，以消除氦气障碍物在同一时间范围内的速度较低的速度，从而在途中降低了该速度的整体成本。进行必要的研究，以使用其MGB2超导丝来开发和制造无氦背景磁铁系统。我们将提供磁铁系统，以查看将其纳入其文艺复兴时期的“系统1000 MRI IGRT系统，并执行成像测试，以验证与目前的NBTI超导磁铁成像系统相比，整体磁铁系统的性能。这将导致与Hyper Tech的MGB基于MGB2基于MGB2的Magnet Magnet Systems的临床验证。 公共卫生相关性：第一个真实的实时MRI图像指导放射治疗（IGRT）系统，即尽管有器官运动，即使有器官运动，将证明具有精确性的恶性肿瘤为恶性肿瘤传递伽马辐射。此外，磁铁系统将比当前使用的磁铁系统更安全，更容易淬火。