Virtual Reality and Functional MRI to Study Drug Craving

虚拟现实和功能性 MRI 来研究药物渴望

• 批准号: 7407663
• 负责人: Anthony P Zuccolotto
• 金额: $ 10.69万
• 依托单位: PSYCHOLOGY SOFTWARE TOOLS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7407663
• 关键词: Alcohols; Algorithms; Area; Behavior; Behavior Therapy; Behavioral; Biofeedback; Brain; Brain imaging; Cigarette; Cigarette Smoker; Client; Clinic; Clinical; Cocaine; Cognitive; Cognitive Therapy; Compatible; Computer software; Cues; Data; Drug Addiction; Emotional; Environment; Evaluation; Facility Construction Funding Category; Feedback; Focus Groups; Foundations; Functional Magnetic Resonance Imaging; Galvanic Skin Response; Goals; Hand; Image Analysis; Imagery; Imaging Techniques; Individual; Interview; Joystick; Laboratories; Learning; Life; Literature; Location; Magnetic Resonance Imaging; Methodology; Methods; Monitor; Numbers; Patients; Pharmaceutical Preparations; Phase; Phobic anxiety disorder; Physiologic Monitoring; Physiological; Protocols documentation; Provider; Published Comment; Range; Rate; Reaction; Reporting; Research; Research Personnel; Respiration; Rewards; Sensory; Signal Transduction; Smoker; Standards of Weights and Measures; Stimulus; System; Techniques; Testing; Time; Training; addiction; craving; desensitization; drug abuser; drug craving; experience; improved; in vivo; interest; neurobehavioral; neuroimaging; nicotine abuse; novel; problem drinker; programs; response; sensory system; simulation; size; tool; user-friendly; validation studies; virtual; virtual reality

I Virtual reality (VR) offers an unprecedented opportunity to study behavior and brain activation in situations much more closely approximating real-life than most laboratory or treatment situations. By immersing subjects in realistic-looking, dynamic, interactive, individualized environments, it is possible to provide stimulus cues of the experimenter s choosing and timing to elicit more intense and controlled reactions from subjects. Our goal is to provide a flexible tool for drug-abuse researchers interested in using virtual reality simulations for neurobehavioral studies, especially in the context of fMRI studies. Our Phase I research has demonstrated that VR can provoke strong cravings in cigarette smokers, both on a subjective rating scale and in brain areas controlling emotional and cognitive responses. We identified a range of stimuli that evoke effective craving. The size of the craving response was as great as that typically reported in the literature, even for in vivo studies. We learned that the strongest cravings can be very specific and idiosyncratic and can be strongly influenced by the dynamics of the environment. In Phase II we intend to use similar behavioral and fMRI techniques to study cravings in larger groups of smokers, alcohol abusers and cocaine abusers and will compare the responses to more standard techniques. A user-friendly interface will be developed that will allow therapists to develop individualized VR worlds directed at the patient as a component of cognitive-behavioral treatment sessions. Physiological monitoring will be added to allow biofeedback to modulate certain aspects of the simulation, either in or out of the MR scanner. This effort will provide the research foundation to support four novel systems targeted to study and treat addiction: 1) a VR brain-imaging research package; 2) a desktop VR-addiction research package; 3) a desktop VR-addiction treatment package; and 4) a VR brain imaging clinical package. This new methodology has the potential to improve the lives of millions of smokers, alcoholics and cocaine addicts through more effective research and xeatment strategies.

虚拟现实（VR）提供了一个前所未有的机会来研究行为和大脑激活， 比大多数实验室或治疗情况更接近真实生活的情况。通过 沉浸在逼真的，动态的，互动的，个性化的环境中，它是可能的， 提供实验者选择和时机的刺激线索，以引出更强烈和更可控的刺激。 受试者的反应。我们的目标是为有兴趣使用的药物滥用研究人员提供一个灵活的工具 神经行为研究的虚拟现实模拟，特别是在fMRI研究的背景下。第一阶段 研究表明，VR可以引起吸烟者的强烈渴望，无论是在主观上， 等级量表和控制情绪和认知反应的大脑区域。我们发现了一系列刺激 唤起有效的渴望。渴望反应的大小与通常报告的一样大。 文献，即使是体内研究。我们了解到最强烈的渴望可能非常具体， 独特的，并能强烈地受到环境动态的影响。在第二阶段，我们打算 使用类似的行为和功能磁共振成像技术来研究更大规模的吸烟者、酗酒者、 和可卡因滥用者，并将这些反应与更标准的技术进行比较。用户友好的界面 将允许治疗师开发针对患者的个性化VR世界， 认知行为治疗课程的组成部分。将增加生理监测， 生物反馈以调节MR扫描仪内或外的模拟的某些方面。这一努力将 提供研究基础，以支持四种针对研究和治疗成瘾的新系统：1）VR 大脑成像研究包; 2）桌面VR成瘾研究包; 3）桌面VR成瘾 治疗包;以及4）VR脑成像临床包。这种新方法有可能 通过更有效的研究，改善数百万吸烟者、酗酒者和可卡因成瘾者的生活， 治疗策略