Detection of cardiac ischemia using magnetocardiography

使用心磁图检测心脏缺血

• 批准号: 7272138
• 负责人: Mark S. DiIorio
• 金额: $ 18.93万
• 依托单位: MAGNESENSORS, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7272138
• 关键词: Accident and Emergency department; Acute myocardial infarction; Address; Admission activity; Aircraft; Algorithms; Ambulatory Care Facilities; American; American Heart Association; Area; Arteries; Beds; Biological Assay; Biological Markers; Blood Tests; Cardiac; Cardiac Myocytes; Cardiology; Cardiovascular system; Chest Pain; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Trials; Computer software; Computers; Condition; Contracts; Country; Critical Care; Data; Data Analyses; Data Collection; Detection; Development; Devices; Diagnosis; Diagnostic; Doctor of Medicine; Doctor of Philosophy; Echocardiography; Electrocardiogram; Electrophysiology (science); Engineering; Environment; Evaluation; Figs - dietary; Film; Goals; Guidelines; Heart; Helium; High temperature of physical object; Home environment; Hospitalization; Hospitals; Image; Institution; Invasive; Ischemia; Journals; Laboratories; Legal patent; Light; Liquid substance; Magnetism; Magnetoencephalography; Maps; Marketing; Measurement; Measures; Medical; Medical center; Medicine; Metals; Monitor; Myocardial Infarction; Myocardial Ischemia; Nature; New Mexico; Noise; Non-Invasive Cancer Detection; Numbers; Operating System; Operative Surgical Procedures; Outcome; Output; Oxygen; Patients; Performance; Personal Satisfaction; Phase; Phase II Clinical Trials; Physics; Placement; Predictive Value; Principal Investigator; Process; Prospective Studies; Publications; Publishing; Range; Research; Research Personnel; Rest; Risk Factors; Signal Transduction; Site; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Societies; Solutions; Source; Standards of Weights and Measures; Structure; Surface; System; Techniques; Technology; Testing; Time; Tissues; Today; United States Food and Drug Administration; United States National Aeronautics and Space Administration; United States National Institutes of Health; Universities; Unstable angina; Vascular blood supply; Week; Work; Writing; anticancer research; base; bean; biomagnetism; clinical application; cold temperature; college; concept; cost; cost effective; cryogenics; day; design; experience; human subject; improved; innovation; instrument; instrumentation; interest; magnetic field; member; neuroimaging; novel; novel diagnostics; prevent; professor; programs; prototype; sensor; size; superconducting quantum interference device; treatment center; two-dimensional

DESCRIPTION (provided by applicant): MagneSensors' program is aimed at developing a novel magnetocardiography (MCG) instrument that uses magnetic sensors for the rapid, non-invasive detection of cardiac ischemia. The proposed MCG instrument takes advantage of ultra-sensitive superconducting quantum interference devices (SQUIDs) to detect the magnetic fields generated by electrical activity in the heart. The program will use innovative high temperature (high-Tc) SQUID technology to produce the portable, lower cost instruments that are necessary for widespread clinical application. Chest pain is the second leading cause of admission in emergency rooms in the U.S and the costs associated with ruling out acute myocardial infarction (AMI) exceeds $3 billion. Existing techniques such as biomarker blood tests and electrocardiography (ECG) are inadequate and unable to prevent adverse outcomes of missed AMI and the huge costs of unnecessary hospitalization. The U.S. market for MCG instrumentation is estimated at near $1 billion in the emergency department alone. Recent published studies have laid the groundwork for the application of MCG to the detection of cardiac ischemia. The presence of ischemic tissue shows up as abnormalities on two-dimensional magnetic field maps produced by MCG. New algorithms have shown that MCG can achieve a high negative predictive value, which is essential for ruling out AMI. The Phase I effort focuses on demonstrating that high-Tc SQUID sensors can be operated in an "unshielded" environment with sufficient sensitivity to detect the necessary cardiac signals. Since the data analysis can use averaged MCG waveforms, the ultimate in SQUID sensitivity is not required. Unshielded measurements of MCG data taken with high-Tc sensors will be compared with MCG data from conventional low-Tc systems to demonstrate that the signal-to-noise of high-Tc sensors is sufficient for detection. Phase I is aimed developing a proof-of-concept capability to justify a Phase II program to build a portable MCG instrument for clinical use and to examine patients in the emergency department.

描述（由申请人提供）：Magnesensors的程序旨在开发一种新型的磁心电图（MCG）仪器，该仪器使用磁性传感器来快速，无创的​​心脏缺血检测。提出的MCG仪器利用超敏感的超导量子干扰装置（鱿鱼）来检测心脏中电活动产生的磁场。该计划将使用创新的高温（高-TC）鱿鱼技术来生产用于广泛临床应用所需的便携式，较低的成本仪器。胸痛是美国急诊室入院的第二大主要原因，与排除急性心肌梗塞（AMI）相关的费用超过30亿美元。现有的技术（例如生物标志物血液测试和心电图）（ECG）不足，无法防止错过的AMI的不利结果以及不必要的住院费用。仅在急诊室就估计，美国MCG仪器市场估计约为10亿美元。最近发表的研究为将MCG应用于心脏缺血的检测奠定了基础。缺血组织的存在是MCG产生的二维磁场图上的异常。新算法表明，MCG可以实现高负预测值，这对于排除AMI至关重要。第一阶段的工作重点是证明高-TC鱿鱼传感器可以在“未屏蔽”环境中操作，并具有足够的敏感性来检测必要的心脏信号。由于数据分析可以使用平均MCG波形，因此不需要鱿鱼灵敏度的最终。将使用高-TC传感器采用的MCG数据的未屏蔽测量与传统低-TC系统的MCG数据进行比较，以证明高-TC传感器的信噪比足以检测。第一阶段的目的是开发概念验证能力，以证明II期计划合理的合理性，以构建一种便携式MCG工具，用于临床使用并检查急诊科的患者。