Detection of cardiac ischemia using magnetocardiography

使用心磁图检测心脏缺血

• 批准号: 7272138
• 负责人: Mark S. DiIorio
• 金额: $ 18.93万
• 依托单位: MAGNESENSORS, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7272138
• 关键词: Accident and Emergency department; Acute myocardial infarction; Address; Admission activity; Aircraft; Algorithms; Ambulatory Care Facilities; American; American Heart Association; Area; Arteries; Beds; Biological Assay; Biological Markers; Blood Tests; Cardiac; Cardiac Myocytes; Cardiology; Cardiovascular system; Chest Pain; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Trials; Computer software; Computers; Condition; Contracts; Country; Critical Care; Data; Data Analyses; Data Collection; Detection; Development; Devices; Diagnosis; Diagnostic; Doctor of Medicine; Doctor of Philosophy; Echocardiography; Electrocardiogram; Electrophysiology (science); Engineering; Environment; Evaluation; Figs - dietary; Film; Goals; Guidelines; Heart; Helium; High temperature of physical object; Home environment; Hospitalization; Hospitals; Image; Institution; Invasive; Ischemia; Journals; Laboratories; Legal patent; Light; Liquid substance; Magnetism; Magnetoencephalography; Maps; Marketing; Measurement; Measures; Medical; Medical center; Medicine; Metals; Monitor; Myocardial Infarction; Myocardial Ischemia; Nature; New Mexico; Noise; Non-Invasive Cancer Detection; Numbers; Operating System; Operative Surgical Procedures; Outcome; Output; Oxygen; Patients; Performance; Personal Satisfaction; Phase; Phase II Clinical Trials; Physics; Placement; Predictive Value; Principal Investigator; Process; Prospective Studies; Publications; Publishing; Range; Research; Research Personnel; Rest; Risk Factors; Signal Transduction; Site; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Societies; Solutions; Source; Standards of Weights and Measures; Structure; Surface; System; Techniques; Technology; Testing; Time; Tissues; Today; United States Food and Drug Administration; United States National Aeronautics and Space Administration; United States National Institutes of Health; Universities; Unstable angina; Vascular blood supply; Week; Work; Writing; anticancer research; base; bean; biomagnetism; clinical application; cold temperature; college; concept; cost; cost effective; cryogenics; day; design; experience; human subject; improved; innovation; instrument; instrumentation; interest; magnetic field; member; neuroimaging; novel; novel diagnostics; prevent; professor; programs; prototype; sensor; size; superconducting quantum interference device; treatment center; two-dimensional

DESCRIPTION (provided by applicant): MagneSensors' program is aimed at developing a novel magnetocardiography (MCG) instrument that uses magnetic sensors for the rapid, non-invasive detection of cardiac ischemia. The proposed MCG instrument takes advantage of ultra-sensitive superconducting quantum interference devices (SQUIDs) to detect the magnetic fields generated by electrical activity in the heart. The program will use innovative high temperature (high-Tc) SQUID technology to produce the portable, lower cost instruments that are necessary for widespread clinical application. Chest pain is the second leading cause of admission in emergency rooms in the U.S and the costs associated with ruling out acute myocardial infarction (AMI) exceeds $3 billion. Existing techniques such as biomarker blood tests and electrocardiography (ECG) are inadequate and unable to prevent adverse outcomes of missed AMI and the huge costs of unnecessary hospitalization. The U.S. market for MCG instrumentation is estimated at near $1 billion in the emergency department alone. Recent published studies have laid the groundwork for the application of MCG to the detection of cardiac ischemia. The presence of ischemic tissue shows up as abnormalities on two-dimensional magnetic field maps produced by MCG. New algorithms have shown that MCG can achieve a high negative predictive value, which is essential for ruling out AMI. The Phase I effort focuses on demonstrating that high-Tc SQUID sensors can be operated in an "unshielded" environment with sufficient sensitivity to detect the necessary cardiac signals. Since the data analysis can use averaged MCG waveforms, the ultimate in SQUID sensitivity is not required. Unshielded measurements of MCG data taken with high-Tc sensors will be compared with MCG data from conventional low-Tc systems to demonstrate that the signal-to-noise of high-Tc sensors is sufficient for detection. Phase I is aimed developing a proof-of-concept capability to justify a Phase II program to build a portable MCG instrument for clinical use and to examine patients in the emergency department.

描述（由申请人提供）：MagneSensors的项目旨在开发一种新型心磁图（MCG）仪器，该仪器使用磁传感器快速、非侵入性检测心脏缺血。所提出的MCG仪器利用超灵敏超导量子干涉器件（SQUID）来检测心脏电活动产生的磁场。该计划将使用创新的高温（高Tc）SQUID技术来生产广泛临床应用所需的便携式、低成本仪器。胸痛是美国急诊室入院的第二大原因，排除急性心肌梗死（AMI）的相关费用超过30亿美元。现有的技术，如生物标志物血液检测和心电图（ECG）是不够的，无法防止遗漏的AMI的不良后果和不必要的住院治疗的巨大成本。据估计，仅在急诊科，美国MCG仪器市场就接近10亿美元。最近发表的研究为MCG在心肌缺血检测中的应用奠定了基础。缺血组织的存在在MCG产生的二维磁场图上显示为异常。新的算法已经表明，MCG可以实现高阴性预测值，这对于排除AMI是必不可少的。第一阶段的工作重点是证明高Tc SQUID传感器可以在“无屏蔽”环境中操作，具有足够的灵敏度来检测必要的心脏信号。由于数据分析可以使用平均MCG波形，因此不需要SQUID灵敏度的极限。使用高Tc传感器采集的MCG数据的非屏蔽测量值将与传统低Tc系统的MCG数据进行比较，以证明高Tc传感器的信噪比足以进行检测。第一阶段旨在开发概念验证能力，以证明第二阶段计划的合理性，以构建便携式MCG仪器用于临床使用，并在急诊科检查患者。