Ottis Media and Obesity
奥蒂斯媒体与肥胖
基本信息
- 批准号:7192239
- 负责人:
- 金额:$ 7.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-03-12 至 2008-02-28
- 项目状态:已结题
- 来源:
- 关键词:AdultAgeAnesthesia proceduresAntibioticsAreaBasic ScienceBehaviorBehavioralBody mass indexBrainChildChildhoodClinicalClinical ResearchCollaborationsCommunicationComplexComputer softwareCuesDataDatabasesDental AnesthesiaDisciplineEarEar DiseasesEatingEducational process of instructingEducational workshopElectronicsEpidemiologyEsthesiaEvaluationEventFemaleFlavoringFoodFood PreferencesFood TechnologyFood and BeveragesFunctional disorderGenetic VariationGeographyHealthHeightIndividualInstitutionIntakeInternetLaboratoriesLaboratory StudyLearningMeasurementMeasuresMethodsMinnesotaMonoclonal Antibody R24NatureNerveObesityOralOral cavityOtitis MediaOtolaryngologistOverweightParticipantPatientsPerceptionPrincipal InvestigatorPropertyPsychophysicsPsychophysiologyQuestionnairesRateRecording of previous eventsRecruitment ActivityResearchResearch DesignResearch PersonnelResourcesRosaSensorySeveritiesSimulateSmell PerceptionTalentsTaste PerceptionTechniquesTestingTranslatingTranslational ResearchTranslationsTubeUniversitiesWeightWorkafferent nervechorda tympaniear infectionexperiencehearing impairmenthedonicimprovedinsightinstrumentlecturesmalemiddle earnovelpathogenpreferenceprogramsresearch studysexsocial
项目摘要
DESCRIPTION (provided by applicant): This application is intended to prepare for the submission of an R01 focused on the growing evidence for an association between otitis media and obesity. A questionnaire given to academic attendees at lectures included demographic information (sex, age, height, weight) and a question about otitis media (Have you ever suffered from middle ear infections? 1) no, 2) yes, but not serious, 3) yes, required antibiotics more than once, or 4) yes, required tubes in ears). Attendees also rated their liking for 26 food/beverage items using a new scale developed to measure food liking in the context of all hedonic experience. This scale .r permits valid comparisons of liking across groups (e.g., groups that differ in history of otitis media). For adults (¿35 years), as otitis media increased in severity, body mass index (BMI) rose; for moderate to severe histories of otitis media, overweight or obesity increased by 35% for females and 27% for males. As otitis media increased in severity, preference for high-calorie foods rose as well. We hypothesize the following sequence of events. Since the chorda tympani taste nerve passes through the middle ear on its way to the brain, the chorda tympani is damaged in the middle ear by pathogens associated with otitis media. The damage to this nerve intensifies some other oral sensations through a release of inhibition mechanism. Because of central connections between oral sensations and retronasal olfaction, damage to this nerve also alters flavor. Alterations in the sensory properties of foods alter preferences for and intake of these foods. Specifically, support is requested to fill in the remaining gaps in this reasoning to prepare for the submission of an R01. First, the otitis media history association with obesity must be verified in properly constituted epidemiological databases. We propose partnerships with the Epidemiology of Hearing Loss and University of Minnesota Center for Otitis Media studies. Verification will support further efforts to determine the mechanism of the association. Second, criteria for otitis media history must be refined with input from otolaryngologists; we have recruited three leaders in this field to guide us. Finally, all of this must be done in the context of expertise in obesity; we have recruited two leaders in this field who also have expertise in potential translation of any results to the clinical problem of obesity.
描述(由申请人提供):本申请旨在准备提交R01,重点关注中耳炎和肥胖之间关联的证据越来越多。一份调查问卷发给参加讲座的学术人员,包括人口统计信息(性别、年龄、身高、体重)和关于中耳炎的问题(你曾经患过中耳感染吗?)1)没有,2)有,但不严重,3)有,不止一次需要抗生素,或4)有,需要耳管。参与者还使用一种新量表对26种食物/饮料进行了评分,该量表用于衡量所有享乐体验中对食物的喜爱程度。这个刻度。R允许对不同群体的喜好进行有效的比较(例如,中耳炎病史不同的群体)。对于成年人(35岁),随着中耳炎严重程度的增加,体重指数(BMI)上升;中度至重度中耳炎病史中,超重或肥胖女性增加35%,男性增加27%。随着中耳炎的严重程度增加,对高热量食物的偏好也增加了。我们假设事件的顺序如下。由于鼓室索味觉神经在通往大脑的路上经过中耳,因此中耳的鼓室索受到与中耳炎相关的病原体的损害。这种神经的损伤通过释放抑制机制加强了其他一些口腔感觉。由于口腔感觉和后鼻嗅觉之间的中枢连接,对该神经的损伤也会改变味道。食物感官特性的改变会改变人们对这些食物的偏好和摄入量。具体来说,请支持填补此推理中的剩余空白,为提交R01做准备。首先,中耳炎与肥胖相关的病史必须在适当建立的流行病学数据库中得到验证。我们建议与听力损失流行病学和明尼苏达大学中耳炎研究中心合作。核查将支持进一步努力确定该协会的机制。其次,中耳炎病史的标准必须根据耳鼻喉科医生的意见加以完善;我们聘请了这方面的三位领导来指导我们。最后,所有这些都必须在肥胖专家的背景下进行;我们已经招募了这一领域的两位领导者,他们也具有将任何结果转化为肥胖临床问题的专业知识。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
LINDA MAY BARTOSHUK其他文献
LINDA MAY BARTOSHUK的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('LINDA MAY BARTOSHUK', 18)}}的其他基金
Integration of retronasal olfaction and taste: Volatile-enhanced Sweetness
鼻后嗅觉和味觉的整合:挥发性增强的甜味
- 批准号:
8575991 - 财政年份:2013
- 资助金额:
$ 7.2万 - 项目类别:
Integration of retronasal olfaction and taste: Volatile-enhanced Sweetness
鼻后嗅觉和味觉的整合:挥发性增强的甜味
- 批准号:
8710147 - 财政年份:2013
- 资助金额:
$ 7.2万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 7.2万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 7.2万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 7.2万 - 项目类别:
Fellowship
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 7.2万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 7.2万 - 项目类别:
Continuing Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 7.2万 - 项目类别:
Standard Grant
The economics of (mis)information in the age of social media
社交媒体时代(错误)信息的经济学
- 批准号:
DP240103257 - 财政年份:2024
- 资助金额:
$ 7.2万 - 项目类别:
Discovery Projects
How age & sex impact the transcriptional control of mammalian muscle growth
你多大
- 批准号:
DP240100408 - 财政年份:2024
- 资助金额:
$ 7.2万 - 项目类别:
Discovery Projects
Supporting teachers and teaching in the age of Artificial Intelligence
支持人工智能时代的教师和教学
- 批准号:
DP240100111 - 财政年份:2024
- 资助金额:
$ 7.2万 - 项目类别:
Discovery Projects
Enhancing Wahkohtowin (Kinship beyond the immediate family) Community-based models of care to reach and support Indigenous and racialized women of reproductive age and pregnant women in Canada for the prevention of congenital syphilis
加强 Wahkohtowin(直系亲属以外的亲属关系)以社区为基础的护理模式,以接触和支持加拿大的土著和种族育龄妇女以及孕妇,预防先天梅毒
- 批准号:
502786 - 财政年份:2024
- 资助金额:
$ 7.2万 - 项目类别:
Directed Grant