Signal Processing And Instrumentation Section

信号处理和仪器部分（SPIS）提供电气，电子，电光，计算机和软件工程专业知识，以NIH校内研究计划的项目，需要生物医学仪器和信号处理系统的发展。这些SPIS合作涉及先进的信号转导和采集;实时信号和图像处理;以及机器人控制系统。大多数合作导致创建新的生物医学/临床系统，仪器和技术，包括定制硬件和特定应用软件。示例技术开发和项目包括：cDNA和蛋白质微阵列;组织微阵列;激光捕获显微切割（LCM）;表达显微切割（xMD）;染色体显微切割;微流体学、微制造和微分析;单分子、DNA和染色质纤维力学和操纵;高速扫描光谱法;原子力显微镜（AFM）;电子顺磁共振（EPR）成像;磁共振成像（MRI）和功能性MRI（fMRI）方法和装置;磁共振弹性成像（MRE）成像;超声成像;正电子发射断层扫描（PET）成像;荧光成像;语音采集和实时自适应处理;生物力学实时步态分析;用于小鼠疼痛研究的神经特异性伤害性测定;非人灵长类母胎监测;和基于视频的自动小鼠活动监测。这些SPIS的能力和成就使该小组成为NIH此类工程研究和开发的协调中心。该部门的研究和开发活动是与NIH研究所科学家的合作努力，并经常导致开发独特的专业生物医学仪器。其他项目涉及系统仿真和信号分析所需的信号和视频处理算法开发。部分的目标需要在先进的模拟和数字电路，生物物理信号转导技术，射频和遥测系统，数字信号处理硬件和软件，可编程逻辑器件，印刷电路板开发，机电设备，光电子，视频成像和基于计算机的仪器信号处理和控制的设计专业知识。

The Signal Processing and Instrumentation Section (SPIS) provides electrical, electronic, electro-optical, computer, and software engineering expertise to the NIH Intramural Research program for projects that require the development of biomedical instrumentation and signal processing systems. These SPIS collaborations involve advanced signal transduction and acquisition; real-time signal and image processing; and robotic control systems. Most collaborations result in the creation of new biomedical/clinical systems, instrumentation, and techniques, comprised of custom hardware and application specific software. Example technology developments and projects include: cDNA and protein microarray; tissue microarray; laser capture microdissection (LCM); expression microdissection (xMD); chromosome microdissection; microfluidics, microfabrication, and microanalysis; single molecule, DNA, and chromatin fiber mechanics and manipulation; high-speed scanning spectrometry; atomic force microscopy (AFM); electron paramagnetic resonance (EPR) imaging; magnetic resonance imaging (MRI) and functional MRI (fMRI) methodologies and devices; magnetic resonance elastography (MRE) imaging; ultrasound imaging; positron emission tomography (PET) imaging; fluorescence imaging; speech acquisition and real-time adaptive processing; biomechanics real-time gait analysis; neuro-specific nociceptive assay for mouse pain studies; nonhuman primate maternal-fetal monitoring; and automated video-based mouse activity monitoring. These SPIS capabilities and accomplishments have established the group as the focal point for this type of engineering research and development at the NIH. The research and development activities of the section are collaborative efforts with NIH Institute scientists, and often result in the development of unique, specialized biomedical instruments. Other projects involve signal and video processing algorithm development required for system simulation and signal analysis. Section goals necessitate design expertise in advanced analog and digital circuitry, biophysical signal transduction techniques, radio-frequency and telemetry systems, digital signal processing hardware and software, programmable logic devices, printed circuit board development, electromechanical devices, opto-electronics, video imaging, and computer based instrumentation for signal processing and control.