Signal Processing And Instrumentation Section

信号处理和仪器科(SPIS)的研究和开发活动是与NIH研究所的科学家合作进行的，需要开发生物医学实验室和临床研究系统、仪器和方法。这些协作中的大多数需要新的方法和设计，而这些方法和设计只有最少的既定标准或技术知识。SPIS员工在工程研究和开发的所有阶段都有深入的技术经验。SPIS的工作人员与他们的合作者一起审查临床和生物医学科学，以制定项目规范。SPIS工作人员评估理论和实践限制，考虑商业可用的技术，并最终提出各种解决方案。SPIS的职责通常包括实际操作的设计、实施、测试、安装、培训、文档编制和定制研究系统或方法的生产。目前的合作项目以及相关的研究研究包括： 1.改良的经尿道电切器； 2.球体生长和组织学的组织培养基质铸型； 3.人腹膜移植人间皮表面原发癌和转移癌的体外活体模型； 4.具有光谱聚焦CARS和受激发射的多模非线性显微镜； 5.小鼠在化学刺激影响下的运动和运动稳定性的视频采集； 6.对一种新的严重认知障碍个体认知测试框架的评价； 7.用于人化骨模型研究的电纺支架的设计和制作； 8.家庭笼式学习记忆监测装置；NIDDK。 9.用于疾病和正常状态分子分析的组织显微解剖(LCM，，XMD，，fTAM)； 10.与癌症治疗研究相关的体内氧气状态的电子顺磁共振成像；NCI，NINDS。 11.自动检测与疼痛相关的小鼠行为的视频监控系统； 12.基于高通量视频的果蝇评估--药物疗效和睡眠研究；NHLBI，NIDDK。 13.基于PNA的HIV-1分子诊断微流控平台；NIDDK，NIBIB。 14.使用非线性光学技术的活体显微技术；NHLBI。 15.运动障碍常规临床评估的基于视频的跟踪系统 16.电场对细胞的影响-作为癌症治疗的评估；NICHD，NIBIB。 17.用于评估成虫苍蝇药物/化学品的高通量系统；NIDDK。 18.用于成像、诊断和病理研究的前列腺切除标本整体切片的先进方法--使用个性化的基于MR的模具在活体前列腺MRI和组织病理学中进行关联；NCI。 19.体感神经元仪的反应 20.前列腺癌多特征定位框架；NCI。 21.前列腺癌新鲜组织引导采集法；NCI。 22.用于表型鉴定和癌症治疗评估的家养环境中啮齿动物连续观察系统(SCORHE)；NCI、NIDDK、NHLBI、NIEHS、FDA。 23.小鼠家庭环境传感器监测；NIDDK，OD，FDA，HHS。 24.定量荧光寿命成像用于疾病检测和监测；NICHD、NCI、NIBIB。 25.肿瘤细胞培养的血管模拟；NCI，NIBIB。 26.OCT和眼睛跟踪的自适应光学视网膜成像； 27.视网膜营养不良研究用小鼠照明系统 28.PRIME-心血管介入；NHLBI，CNMC。 29.用光片显微镜了解果蝇诱发运动序列的产生 30.通过生物反应器和3D凝胶进行视网膜工程治疗；NEI，NIBIB。 31.蛋白质组装动力学的分析超速离心法 32.时间SPIM图像中线虫胚胎跟踪；NIBIB。 33.骨生长板软骨颗粒培养生物反应器；NICHD。 34.啮齿动物前庭感觉诱发电位的研究技术。 35.正常和疾病宫颈组织的定量特征；NICHD，NHLBI。 36.放射化学实验室仪器和自动化使放射性示踪剂开发和临床前神经成像研究； 37.造血干细胞骨髓生物反应器；NHLBI； 38.便携式非现场肿瘤成像荧光摄像系统 39.用于控制活生物组织(脑/脊柱)研究的微操作器的基于图像的机器人定位系统。 40.胎盘近红外实时血氧测定仪 41.失真产物耳声发射系统 42.用于神经元回路研究的小鼠胡须监测。 43.新一代电休克治疗系统 44.用于分子分析和生物医学研究的微流体、微制造和微分析技术 45.淋巴器官三维组织培养生物反应器；

The research and development activities of the Signal Processing and Instrumentation Section (SPIS) are collaborative efforts with NIH Institute scientists that require the development of biomedical laboratory and clinical research systems, instrumentation, and methodologies. The majority of these collaborations require novel approaches and designs for which there are minimal established criteria or technical knowledge. SPIS staff have in-depth technical experience in all phases of engineering research and development. With their collaborators, SPIS staff review the clinical and biomedical sciences to formulate project specifications. SPIS staff evaluate the theoretical and practical constraints, consider commercially available technologies, and finally propose various solutions. SPIS responsibilities often continue with the hands-on design, implementation, testing, installation, training, documentation, and production of a custom research system or methodology. Current collaborative projects, as well as associated research studies include: 1. Improved Transurethral Resection Device; NCI. 2. Tissue Culture Matrix Casting for Spheroid Growth and Histology; NCI. 3. Ex Vivo Model Using Human Peritoneum for Primary and Metastatic Cancer of Human Mesothelial Surfaces; NCI. 4. Multimodal Nonlinear Microscopy with Spectral-focusing CARS and Stimulated Emission; NHLBI. 5. Video Acquisition of Mouse Locomotion and Motor Stability when Impacted by Chemogenetic Stimulation; NINDS. 6. Evaluation of a Novel Cognitive Testing Framework for Individuals with Severe Cognitive Impairment; NIMH. 7. Design and Fabrication of Electrospun Scaffolds for the Study of Humanized Bone Models; NCI. 8. Home-cage Mouse Monitoring Device for Learning and Memory; NIDDK. 9. Tissue Microdissection for Molecular Analysis of Disease and Normal States (LCM, TAM, xMD, TAM, fTAM); NICHD, NIDA, NIBIB, NCI, NIMH. 10. Electron Paramagnetic Resonance Imaging of In Vivo Oxygen Status Associated with Cancer Treatment Studies; NCI, NINDS. 11. Video Monitoring System for Automated Detection of Pain Related Mice Behaviors; NIDDK. 12. High-throughput Video-based Assessment of Drosophila - Drug Efficacy & Sleep Studies; NHLBI, NIDDK. 13. Microfluidic Platform for PNA-Based Molecular Diagnostics of HIV-1; NIDDK, NIBIB. 14. Intra-vital Microscopy Using Non-linear Optical Techniques; NHLBI. 15. Video-Based Tracking System for the Routine Clinical Evaluation of Motor Disorders; NIDA, NIA. 16. Electric Field Effects on Cells - Evaluation as Cancer Therapy; NICHD, NIBIB. 17. High-throughput Systems to Evaluate Drug/Chemicals in Adult Flies; NIDDK. 18. Advanced Methods of Whole Mount Sectioning of Prostatectomy Specimens for Imaging, Diagnosis, and Pathology Studies - Correlating In Vivo Prostate MRI and Histopathology using Individualized MR-Based Molds; NCI. 19. Response of Somatosensory Neurons Instrumentation; NCCIH. 20. Multi-characteristic Framework for Prostate Cancer Localization; NCI. 21. Prostate Tumor Fresh Tissue Guided Procurement Methods; NCI. 22. System for Continuous Observation of Rodents in Home-cage Environment (SCORHE) for Phenotyping and Cancer Treatment Evaluation; NCI, NIDDK, NHLBI, NIEHS, FDA. 23. Mouse Homecage Environmental Monitoring with Sensors; NIDDK, OD, FDA, HHS. 24. Quantitative Fluorescence Lifetime Imaging for Disease Detection and Monitoring; NICHD, NCI, NIBIB. 25. Vessel Mimetics for Cancer Cell Culture; NCI, NIBIB. 26. OCT and Adaptive Optics Retinal Imaging with Eye Tracking; NEI. 27. Mouse Illumination System for Retinal Dystrophy Studies; NEI. 28. PRiME - Cardiovascular Intervention; NHLBI, CNMC. 29. Using Light-sheet Microscopy to Understand Evoked Motor Sequence Generation in Drosophila; NIMH. 30. Engineering Retinal Therapies via Bioreactors & 3D Gels; NEI, NIBIB. 31. Analytical Ultracentrifugation for Protein Assembly Dynamics; NIBIB. 32. C. Elegans Embryo Tracking in Temporal SPIM Images; NIBIB. 33. Bone Growth Plate Cartilage Pellet Culture Bioreactor; NICHD. 34. Technologies to Study Rodent Vestibular Sensory Evoked Potentials; NIDCD. 35. Quantitative Characterization of Normal and Disease Cervix Tissue; NICHD, NHLBI. 36. Radiochemistry Laboratory Instrumentation and Automation Enabling Radiotracer Development and Preclinical Neuroimaging Research; NIAAA. 37. Hematopoietic Stem Cell Bone Marrow Bioreactor; NHLBI, NIBIB. 38. Portable Fluorescence Camera System for Offsite Tumor Imaging; NCI, NIBIB. 39. Image-Based Robotic Targeting System to Control Micromanipulators for Living Biological Tissues (Brain/Spinal) Studies; NINDS. 40. Placenta Real-time Oximetry Using Near Infrared Spectroscopy; NICHD. 41. Distortion Product Otoacoustic Emissions System; NIDCD. 42. Mouse Whisker Monitoring for Neuronal Circuit Studies; NIMH. 43. Next Generation Electroconvulsive Therapy System; NIMH. 44. Microfluidics, Microfabrication, and Microanalysis Technologies for Molecular Analysis and Biomedical Research; NIBIB, NIST. 45. Lymphoid Organ 3D Tissue Culture Bioreactor; NIAID.