Signal Processing And Instrumentation Section

信号处理和仪器部（SPIS）为需要开发生物医学仪器和信号处理系统的项目提供电气、电子、光电、计算机和软件工程专业知识。这些SPIS合作涉及先进的信号转导和获取；实时信号和图像处理；以及机器人控制系统。大多数合作的结果是创建新的生物医学仪器技术，包括定制硬件和特定应用软件。技术发展和项目的例子包括：cDNA和蛋白质微阵列；组织微阵列;激光捕获显微解剖；表达显微解剖（xMD）；染色体显微解剖;微流体、微加工和微分析；单分子、DNA和染色质纤维的力学和操作；高速扫描光谱法；原子力显微镜（AFM）；电子顺磁共振成像；磁共振成像（MRI）和功能磁共振成像（fMRI）方法和设备；磁共振弹性成像；超声成像;正电子发射断层成像（PET）；荧光成像技术;语音采集与实时自适应处理；小鼠疼痛研究的神经特异性伤害性实验；非人灵长类动物母胎监测；以及基于视频的自动鼠标活动监控。这些SPIS的能力和成就使该小组成为美国国立卫生研究院这类工程研究和开发的焦点。该科的研究和发展活动是与美国国立卫生研究院科学家的合作努力，并经常导致独特的，专门的生物医学仪器的发展。其他项目涉及系统仿真和信号分析所需的信号和视频处理算法开发。部分目标需要先进的模拟和数字电路，生物物理信号转导技术，射频和遥测系统，数字信号处理硬件和软件，可编程逻辑设备，印刷电路板开发，机电设备，光电子，视频成像和基于计算机的信号处理和控制仪器的设计专业知识。

The Signal Processing and Instrumentation Section (SPIS) provides electrical, electronic, electro-optical, computer, and software engineering expertise to the NIH Intramural Research program for projects that require the development of biomedical instrumentation and signal processing systems. These SPIS collaborations involve advanced signal transduction and acquisition; real-time signal and image processing; and robotic control systems. Most collaborations result in the creation of new biomedical instrumentation technologies comprising of custom hardware and application specific software. Example technology developments and projects include: cDNA and protein microarray; tissue microarray; laser capture microdissection (LCM); expression microdissection (xMD); chromosome microdissection; microfluidics, microfabrication, and microanalysis; single molecule, DNA, and chromatin fiber mechanics and manipulation; high-speed scanning spectrometry; atomic force microscopy (AFM); electron paramagnetic resonance (EPR) imaging; magnetic resonance imaging (MRI) and functional MRI (fMRI) methodologies and devices; magnetic resonance elastography (MRE) imaging; ultrasound imaging; positron emission tomography (PET) imaging; fluorescence imaging; speech acquisition and real-time adaptive processing; neuro-specific nociceptive assay for mouse pain studies; nonhuman primate maternal-fetal monitoring; and automated video-based mouse activity monitoring. These SPIS capabilities and accomplishments have established the group as the focal point for this type of engineering research and development at the NIH. The research and development activities of the section are collaborative efforts with NIH Institute scientists, and often result in the development of unique, specialized biomedical instruments. Other projects involve signal and video processing algorithm development required for system simulation and signal analysis. Section goals necessitate design expertise in advanced analog and digital circuitry, biophysical signal transduction techniques, radio-frequency and telemetry systems, digital signal processing hardware and software, programmable logic devices, printed circuit board development, electromechanical devices, opto-electronics, video imaging, and computer based instrumentation for signal processing and control.