Signal Processing And Instrumentation Section

信号处理和仪器科（SPIS）的研究和开发活动是与NIH研究所的科学家合作进行的，需要开发生物医学实验室和临床研究系统、仪器和方法。这些合作中的大多数都需要新颖的方法和设计，而这些方法和设计只有很少的既定标准或技术知识。SPIS员工在工程研发的各个阶段都有丰富的技术经验。SPIS的工作人员与其合作者一起审查临床和生物医学科学，以制定项目规格。SPIS工作人员评估理论和实践限制，考虑商业上可用的技术，最后提出各种解决方案。SPIS的职责通常是继续动手设计、实施、测试、安装、培训、文档和定制研究系统或方法的生产。目前的合作项目以及相关的研究包括：

The research and development activities of the Signal Processing and Instrumentation Section (SPIS) are collaborative efforts with NIH Institute scientists that require the development of biomedical laboratory and clinical research systems, instrumentation, and methodologies. The majority of these collaborations require novel approaches and designs for which there are minimal established criteria or technical knowledge. SPIS staff have in-depth technical experience in all phases of engineering research and development. With their collaborators, SPIS staff review the clinical and biomedical sciences to formulate project specifications. SPIS staff evaluate the theoretical and practical constraints, consider commercially available technologies, and finally propose various solutions. SPIS responsibilities often continue with the hands-on design, implementation, testing, installation, training, documentation, and production of a custom research system or methodology. Current collaborative projects, as well as associated research studies include: 1. 2D Microfluidic Device Setup to Combine the Controlled Delivery of Oxygen with Real-Time Measurement of Intracellular Oxygen Concentration and Metabolism in vitro; NCI, NHLBI, NIBIB 2. 3D Printed Tenodesis Type Action Hand Prosthesis for Pediatric Rehabilitation; CC 3. 3D Printing Applications in Analytical Ultracentrifugation Technologies; NIBIB 4. 3D QR Code-like Cuboid as a Proposed Measurement Standard; CC 5. 3D-printed Mold to Generate Agarose Cavities for Mouse Embryo Dissection; CC 6. An ex vivo Model using Human Peritoneum for Primary and Metastatic Cancer or Human Mesothelial Surfaces; NCI 7. Assistive Fiber Optic Implant Holder for Mouse Surgery; NIAAA 8. Augmented Reality Application for Interactive Enhancements for Scientific Data Visualization and Manipulation; NICHD 9. Automation of Tissue Staining Pipeline for Multiplex Antibody Assays and Histopathology; NCI 10. C. Elegans Embryo Tracking in Temporal SPIM Volumetric Images; NIBIB 11. Characterizing Spontaneous Movements During Early Development of Mice; NIMH 12. COVID-19 Autopsy Containment Box; NCI, NIMH 13. CT Lung Visualization using VR/AR Technology; CC, UMBC 14. Custom-made Macaque Brain Molds to Correlate MR Imaging to Whole-brain Histology; NICHD 15. Development and Characterization of a Handheld Diffuse Optical Spectroscopy System; NICHD 16. Development of Advanced Analytical Ultracentrifugation Fluorescence Detectors and Acquisition Systems to Study the Dynamics of Protein Assemblies; NIBIB 17. Development of Ear Savers to Reduce Ear Strain from Face Masks for COVID-19 Pandemic; CC, NCI, OD 18. Development of Multi-modality Imaging Techniques; NICHD, NCI 19. Development of Multi-Well Incubation Chamber for Rodent Brain Tissue Studies; NIMH 20. Diffusion Exchange Functional MRI; NICHD 21. Evaluation of 3D-printed Nasopharyngeal Swabs to Address COVID Supply Shortages; NIAID, Childrens National, WRNMMC 22. Evaluation of a Novel Cognitive Testing Framework for Individuals with Severe Cognitive Impairment; NIMH 23. Fetal Brain DWI Imaging, Reconstructions, and 3D Rendering/Analysis; NICHD 24. Functional Near Infrared Spectroscopy System (fNIRS) for Brain Imaging; NICHD 25. Hands-free 3D-printed Door Opener to Minimize Spread of Coronavirus; NCI 26. Home-Cage Monitoring Device for Learning and Memory; NIDDK 27. Illumination Control System for Mouse Visual Cycle Studies Relating to Retinal Dystrophies; NEI 28. Imaging Flow in Capillary Structures with Low Flowrates and Veinous like Exchange; NICHD 29. Imaging/Interrogation of Metastatic Colonization in Perfused Resected Liver; NCI, NIBIB 30. Implementation of a Novel Tumor Model System for Interrogation of the Metastatic Cascade and Drug Development; NCI 31. Implementation of Augmented Reality in MRI Guided Prostate Biopsies; NCI, CC 32. Improved Restricted Exchange Environmental Chamber (REEC); NCI, NIBIB 33. Improved Transurethral Resection (TUR) Device; NCI 34. Instrumentation Design and Fabrication with NIMH and NINDS; NIMH 35. Instrumentation to Measure Response Properties of Somatosensory Neurons; NCCIH 36. Internet Devices for Improving Animal Care (IDIA-Care) - Cloud Analytics for Research Environments; NIDDK, OD, FDA 37. Intra-vital Microscopy Using Non-linear Optical Techniques; NHLBI 38. Investigation of Pituitary Tumors and Related Hypothalamic Disorders using Multi-modality Imaging Techniques; NICHD 39. Investigation of Short- and Long-term Effects of COVID-19 on Cognitive Functions; NICHD 40. Laser Welder for Sterile Filling of Tubing for Hyperpolarized MRI Experiments; NCI, CC 41. Methods for Soft Tissue Prostate Procurement using Patient-specific MRI-based Guiding Fixture; NCI 42. Microfabricated Polymeric Vessel Mimetics for Cancer Cell Culture; NCI, NIBIB 43. Microfluidics; Microfabrication; and Microanalysis Technologies for Biomedical Research; NIBIB 44. Mirror Neuron Network Dysfunction as an Early Biomarker of Neurodevelopmental Disorder; NICHD 45. Mouse Catheterization Holder to Instill Bladder Tumor Cells into the Bladder; NCI 46. Mouse Whisker Tracking and Texture Preference for Brain Neural Circuit Studies (Behavior Box & Fixed-head Condition); NIMH 47. MRI Elastography for Anisotropic Materials; NICHD 48. Multimodal Nonlinear Microscopy with Spectral-focusing CARS and Stimulated Emission; NHLBI 49. Next Generation Electroconvulsive Therapy (ECT) System; NIMH 50. NIH Equipment Monitoring System; NIDDK, NIAID, NHLBI 51. OCT - Adaptive Optics Retinal Imaging with Eye Tracking; NEI 52. Pellet Culture (3D) Bioreactor for In Vitro Cultivation of Bone Growth Plate Cartilage Tissue; NICHD 53. Portable Fluorescence Camera System for Offsite Ovarian Tumor Imaging; NCI, University of Tokyo 54. Portable Low-Field Magnetic Resonance Imager; NICHD 55. PRiME: Physiological Recording in MRI Environment for Cardiovascular Intervention; NHLBI, Children's National, Children's Hospital Dallas, UC San Diego Children's Hospital, PinMed Inc 56. Prostate Methods Correlating Multiparametric MRI with Histopathology of Prostatectomy Specimens using Patient-specific MRI-based Prostate Mold; NCI 57. Rapidscan Continuous Wave Electron Paramagnetic Resonance Imaging of Nitroxide Reduction for Redox Status of Tissue; NCI 58. Real-time Oximetry of Anterior Placenta Using Near Infrared Spectroscopy; NICHD 59. Rodent Arena Tracker (RAT); NIDDK 60. Self-Collection Homebased Biosensor for Monitoring and Tracking Suspected COVID-19 Patients; NICHD 61. SLO - Adaptive Optics Retinal Imaging with Eye Tracking; NEI 62. System for Continuous Observation of Rodents in Home-cage Environment (SCORHE): NCI, NHLBI, NIDDK, NIEHS, NINDS, FDA 63. System to Measure Rodent Vestibular Sensory Evoked Potentials; NIDCD 64. Therapeutic Application of Induced Electromagnetic Fields (EMFs) to Reduce Cell Growth and Migration in Glioblastoma Multiforme (GBM); NICHD, NCI, NINDS, NIBIB, Celopics Inc 65. Time Domain Electron Paramagnetic Resonance Imaging of Oxygen Status Corresponding to Cancer Treatments; NCI 66. Tissue Microdissection for Macromolecular Analysis of Normal Development and Pathology; NICHD, NIBIB, NCI, XMD Diagnostics LLC 67. Using Light-sheet Microscopy to Understand Evoked Motor Sequence Generation in Drosophila; NIMH, NIBIB 68. Video Acquisition of Mouse Locomotion and Motor Stability when Impacted by Chemogenetic Stimulation; NINDS 69. Video Analysis System for Behavior and Activity Assessment of Fruit-Flies in High-Throughput Studies; NIDDK, NHLBI 70. Video Monitoring System for Automated Detection of Pain Related Mice Behaviors; NIDDK 71. Video-Based Breathing Rate Detection for COVID-19 Hamsters; FDA 72. Walk-away Radiochemistry Laboratory Automation; NIAAA 73. X-clometer - New Radiographic Marker; CC