BIOANALYTICAL SHARED RESOURCES

生物分析共享资源

• 批准号: 7495648
• 负责人: DAVID L HACHEY
• 金额: $ 21.83万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7495648
• 关键词: Arts; Biological Assay; Cancer Center; Cells; Collaborations; Communities; Core Facility; DNA Adducts; Electrospray Ionization; Experimental Designs; Facility Accesses; Faculty; Fees and Charges; Floor; Funding; Growth; Image; Individual; Ions; Laboratories; Laboratory Personnel; Leadership; Learning; Maintenance; Mass Spectrum Analysis; Medical Research; Mission; Monitor; Operative Surgical Procedures; Performance; Pharmaceutical Preparations; Procedures; Program Research Project Grants; Proteins; Proteomics; Proteomics Shared Resource; Provider; Quality Control; Recording of previous events; Records; Reporting; Research; Research Personnel; Resource Sharing; Resources; Running; Sampling; Services; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Standards of Weights and Measures; Students; System; Techniques; Technology; The Vanderbilt-Ingram Cancer Center at the Vanderbilt University; Time; Tissues; Training Programs; Universities; Work; analytical method; base; cost; cost effective; design; desire; foot; innovation; instrument; instrumentation; investigator training; liquid chromatography mass spectrometry; mass spectrometer; medical schools; programs; protein metabolite; research study; small molecule

The mission of the Bioanalytical Shared Resource (BSR) is to provide cost-effective, state-of-the-art instrumentation and analytical expertise to VICC investigators. The BSR is used for identification and characterization of small molecules such as drugs and drug metabolites, protein and DNA adducts and for qualitative and quantitative assays of endogenous metabolites in tissues and cells. Laboratory personnel assist users in developing analytical methods, designing experiments, developing standard operating procedures, maintaining quality control records on instrument performance and maintenance histories, performing routine assays for investigators, and training students and fellows in the theoretical and practical aspects of MS. As new techniques become better understood, they are made available to the user community through the Shared Resource. Thus the BSR satisfies the routine analytical needs of investigators and also makes available new analytical capabilities for research problems demanding more innovative solutions that are beyond the scope of a service laboratory. Dr. David Hachey is Manager of the Bioanalytical Shared Resource. He works closely with Dr. Daniel Liebler, Director of the Proteomics Shared Resource, and Dr. Richard Caprioli, Director of the Tissue Protein Profiling/Imaging Shared Resource. All three work out of the Vanderbilt University Mass Spectrometry Research Center.

生物分析共享资源（BSR）的使命是为VICC研究者提供具有成本效益的最先进仪器和分析专业知识。BSR可用于药物和药物代谢物、蛋白质和DNA加合物等小分子的鉴定和表征，以及组织和细胞中内源性代谢物的定性和定量分析。实验室人员协助用户开发分析方法，设计实验，开发标准操作程序，维护仪器性能和维护历史的质量控制记录，为研究人员进行常规测定，并在MS的理论和实践方面培训学生和研究员。 社区通过共享资源。因此，BSR满足以下常规分析需求： 研究人员还提供了新的分析能力，以研究需要更多创新解决方案的问题，这些解决方案超出了服务实验室的范围。 博士大卫Hachey是生物分析共享资源经理。他与蛋白质组学共享资源主任丹尼尔利布勒博士和组织蛋白质分析/成像共享资源主任理查德卡普里奥利博士密切合作。这三个人都在范德比尔特大学质谱研究中心工作。