BIOANALYTICAL SHARED RESOURCES

生物分析共享资源

基本信息

批准号：
7495648
负责人：
DAVID L HACHEY
金额：
$ 21.83万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7495648
关键词：
Arts Biological Assay Cancer Center Cells Collaborations Communities Core Facility DNA Adducts Electrospray Ionization Experimental Designs Facility Accesses Faculty Fees and Charges Floor Funding Growth Image Individual Ions Laboratories Laboratory Personnel Leadership Learning Maintenance Mass Spectrum Analysis Medical Research Mission Monitor Operative Surgical Procedures Performance Pharmaceutical Preparations Procedures Program Research Project Grants Proteins Proteomics Proteomics Shared Resource Provider Quality Control Recording of previous events Records Reporting Research Research Personnel Resource Sharing Resources Running Sampling Services Solutions Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Standards of Weights and Measures Students System Techniques Technology The Vanderbilt-Ingram Cancer Center at the Vanderbilt University Time Tissues Training Programs Universities Work analytical method base cost cost effective design desire foot innovation instrument instrumentation investigator training liquid chromatography mass spectrometry mass spectrometer medical schools programs protein metabolite research study small molecule

项目摘要

The mission of the Bioanalytical Shared Resource (BSR) is to provide cost-effective, state-of-the-art instrumentation and analytical expertise to VICC investigators. The BSR is used for identification and characterization of small molecules such as drugs and drug metabolites, protein and DNA adducts and for qualitative and quantitative assays of endogenous metabolites in tissues and cells. Laboratory personnel assist users in developing analytical methods, designing experiments, developing standard operating procedures, maintaining quality control records on instrument performance and maintenance histories, performing routine assays for investigators, and training students and fellows in the theoretical and practical aspects of MS. As new techniques become better understood, they are made available to the user community through the Shared Resource. Thus the BSR satisfies the routine analytical needs of investigators and also makes available new analytical capabilities for research problems demanding more innovative solutions that are beyond the scope of a service laboratory. Dr. David Hachey is Manager of the Bioanalytical Shared Resource. He works closely with Dr. Daniel Liebler, Director of the Proteomics Shared Resource, and Dr. Richard Caprioli, Director of the Tissue Protein Profiling/Imaging Shared Resource. All three work out of the Vanderbilt University Mass Spectrometry Research Center.

生物分析共享资源（BSR）的使命是为VICC研究人员提供具有成本效益，最先进的仪器和分析专业知识。 BSR用于鉴定和表征小分子，例如药物和药物代谢产物，蛋白质和DNA加合物以及组织和细胞中内源性代谢物的定性和定量测定。实验室人员协助用户开发分析方法，设计实验，制定标准操作程序，维持有关仪器性能和维护历史的质量控制记录，为调查人员执行常规测定，以及在MS的理论和实际方面培训学生和研究员。随着新技术变得更好地理解，用户可以使用它们通过共享资源进行社区。因此，BSR满足了常规分析需求调查人员，还为研究问题提供了新的分析能力，要求需要更具创新的解决方案，这些解决方案超出了服务实验室的范围。 David Hachey博士是生物分析共享资源的经理。他与蛋白质组学共享资源总监Daniel Liebler博士以及组织蛋白质分析/成像共享资源的主管Richard Caprioli博士与他合作。这三个工作都在范德比尔特大学质谱研究中心工作。