BIOANALYTICAL SHARED RESOURCES

生物分析共享资源

• 批准号: 7116934
• 负责人: DAVID L HACHEY
• 金额: $ 7.6万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7116934
• 关键词: adduct; analytical method; biomedical facility; experimental designs; method development; neoplasm /cancer; small molecule

The mission of the Bioanalytical Shared Resource (BSR) is to provide cost-effective, state-of-the-art instrumentation and analytical expertise to VICC investigators. The BSR is used for identification and characterization of small molecules such as drugs and drug metabolites, protein and DNA adducts and for qualitative and quantitative assays of endogenous metabolites in tissues and cells. Laboratory personnel assist users in developing analytical methods, designing experiments, developing standard operating procedures, maintaining quality control records on instrument performance and maintenance histories, performing routine assays for investigators, and training students and fellows in the theoretical and practical aspects of MS. As new techniques become better understood, they are made available to the user community through the Shared Resource. Thus the BSR satisfies the routine analytical needs of investigators and also makes available new analytical capabilities for research problems demanding more innovative solutions that are beyond the scope of a service laboratory. Dr. David Hachey is Manager of the Bioanalytical Shared Resource. He works closely with Dr. Daniel Liebler, Director of the Proteomics Shared Resource, and Dr. Richard Caprioli, Director of the Tissue Protein Profiling/Imaging Shared Resource. All three work out of the Vanderbilt University Mass Spectrometry Research Center.

生物分析共享资源(BSR)的使命是为VICC调查人员提供具有成本效益的、最先进的仪器和分析专业知识。BSR用于药物和药物代谢物、蛋白质和DNA加合物等小分子的鉴定和表征，以及组织和细胞中内源性代谢物的定性和定量分析。实验室人员协助用户开发分析方法，设计实验，开发标准操作程序，维护仪器性能和维护历史的质量控制记录，为研究人员执行常规分析，并在MS的理论和实践方面培训学生和研究员。随着新技术得到更好的理解，用户可以使用这些技术 通过共享资源创建社区。因此，BSR满足了常规分析的需要 此外，它还为研究人员提供了新的分析能力，可用于需要更多创新解决方案的研究问题，而这些问题超出了服务实验室的范围。 大卫·哈奇博士是生物分析共享资源的经理。他与蛋白质组学共享资源主任Daniel Liebler博士和组织蛋白质图谱/成像共享资源主任Richard Caprioli博士密切合作。这三个人都在范德比尔特大学质谱学研究中心工作。