Mechanical Force and Neural Regeneration

机械力与神经再生

• 批准号: 7515857
• 负责人: AKIRA CHIBA
• 金额: $ 29.77万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7515857
• 关键词: Bioinformatics; Biomedical Engineering; Cells; Chromosome Pairing; Evolution; Facial Injuries; Foundations; Genetic; Individual; Injury; Mechanics; Nanotechnology; Natural regeneration; Nerve Regeneration; Neuraxis; Neurons; Property; Public Health; Regenerative Medicine; Synapses; Testing; Work; base; concept; in vivo; novel; novel strategies; relating to nervous system; restoration

DESCRIPTION (provided by applicant): This project aims at causing a major paradigm-shift in regenerative medicine. In the past, attempts to re-establish synaptic connectivity following injury have met great difficulties. A new work yielded evidence that mechanical force, applied either naturally or artificially at individual nascent synapses, initiates and enhances their connectivity. This FORCE (force orchestrated retrograde synaptic enhancement) mechanism is likely based on a property of cells conserved through evolution and, thus, has the potential to apply widely including regenerative medicine. In this project, we seek to establish the basis for novel strategies that make synaptic restoration possible. Genetics, bioengineering, computational bioinformatics and nanotechnology will be combined to test the hypothesis: mechanical force not only initiates and enhances but also restores neural connectivity. If successful, this project will shift the focus in regenerative medicine from moleculo-centric to mechano-centric approaches. PUBLIC HEALTH RELEVANCE: This project aims to introduce an important new concept to regenerative neuromedicine. Regeneration of central nervous system neurons after injury faces daunting challenges. We propose to explore the potential of mechanical force being an integral part of initiation, enhancement and restoration of synapses in vivo and, thereby, seek to establish a foundation for novel neural restoration strategies.

描述(由申请者提供)：该项目旨在引起再生医学的重大范式转变。在过去，在损伤后重建突触连接的尝试遇到了很大的困难。一项新的研究证明，无论是自然施加还是人工施加在单个新生突触上的机械力，都会启动并增强它们的连接性。这种FORCE(强制协调的逆行突触增强)机制可能是基于细胞在进化过程中保持不变的特性，因此具有广泛应用的潜力，包括再生医学。在这个项目中，我们寻求建立使突触恢复成为可能的新策略的基础。遗传学、生物工程、计算生物信息学和纳米技术将结合起来检验这一假设：机械力不仅可以启动和增强，还可以恢复神经连接。如果成功，该项目将把再生医学的重点从以分子为中心转向以机械为中心。公共卫生相关性：该项目旨在为再生神经医学引入一个重要的新概念。中枢神经系统损伤后神经元的再生面临着严峻的挑战。我们建议探索机械力在体内突触的启动、增强和恢复中的潜力，从而寻求为新的神经恢复策略建立基础。