Molecular mechanisms of dendritic guidance

树突引导的分子机制

• 批准号: 7218593
• 负责人: AKIRA CHIBA
• 金额: $ 27.94万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-08 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7218593
• 关键词: Abreaction; Affect; Attention; Brain; Cells; Cytoplasmic Tail; Dendrites; Development; Disease; Docking; Drosophila genus; Embryonic Nervous System; Genetic; Mammals; Molecular; Neuraxis; Neurites; Neurons; Neurosciences; Outcome; Process; Signal Pathway; Signaling Molecule; Soluble Guanylate Cyclase; Synapses; Testing; Thinking; Time; Work; atypical protein kinase C; axon guidance; in vivo; novel; receptor

DESCRIPTION (provided by applicant): The mechanisms by which the wiring of the central nervous system is established during development are an important topic of basic neuroscience. Although much attention has been paid to the mechanisms of axon guidance, there are major gaps in our understanding of the processes used by dendrites to establish specific synaptic connections. This project uses the tractable Drosophila embryonic nervous system to tease apart the mechanisms of dendritic guidance. The previous and preliminary results show unexpected and novel aspects of this process that are very likely to have an important impact on how we think about molecules involved in pathfinding. Although previously identified molecules are being studied, the evidence so far obtained makes a clear case that the same molecules work in different ways in specific neurites within the same neuron, and that different identified neurons may use the same set of molecules in different ways. A set of integrated hypotheses, each of which can be adapted to general situations, will be tested by this project. If successful, outcome of this project will provide a much-needed background to understanding the cause of diseases that affect brain connectivity.

描述（申请人提供）：中枢神经系统在发育过程中形成的机制是基础神经科学的一个重要课题。尽管人们对轴突引导的机制给予了很多关注，但我们对树突建立特定突触连接的过程的理解仍存在重大空白。这个项目使用易处理的果蝇胚胎神经系统来梳理树突引导的机制。先前和初步的结果显示了这一过程意想不到的和新颖的方面，很可能对我们如何看待参与寻路的分子产生重要影响。虽然先前确定的分子正在研究中，但迄今为止获得的证据清楚地表明，相同的分子在同一神经元内的特定神经突中以不同的方式起作用，并且不同的已确定的神经元可能以不同的方式使用同一组分子。本项目将测试一系列综合假设，每一个假设都可以适应一般情况。如果成功，这个项目的结果将为了解影响大脑连接的疾病的原因提供急需的背景。