IMMUNE RESP IN NEONATAL HOUSE DUST MITE-SENSITIZED MONKEYS FOL EXPTO OZONE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目的：吸入性皮质类固醇（ICS）常用于治疗幼儿持续性哮喘，但这种治疗方式在生命第一年的安全性和有效性尚不清楚。我们以前曾报道，暴露方案的屋尘螨（HDM）气溶胶和臭氧的结果在发展中的气道高反应性和嗜酸性粒细胞增多症在6个月大的婴儿恒河猴。在目前的研究中，我们确定ICS治疗是否可以预防或减轻儿童哮喘动物模型的气道炎症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Inhaled corticosteroids (ICS) are frequently used to treat persistent asthma in young children, however the safety and efficacy of this therapeutic modality during the first year of life is not known. We have previously reported that an exposure regimen of house dust mite (HDM) aerosol and ozone results in the development of airway hyperresponsiveness and eosinophilia in 6 month old infant rhesus monkeys. In the current study, we determined if ICS treatment can prevent or attenutate airways inflammation in this animal model of childhood asthma.