IMMUNE RESP IN NEONATAL HOUSE DUST MITE-SENSITIZED MONKEYS FOL EXPTO OZONE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 吸入皮质类固醇(ICS)经常用于治疗幼儿持续性哮喘，但这种治疗方法在生命第一年的安全性和有效性尚不清楚。我们以前曾报道，暴露于室内尘螨(HDM)气溶胶和臭氧的方案会导致6个月大的恒河猴呼吸道高反应性和嗜酸性粒细胞增多。在目前的研究中，我们确定了ICS治疗是否可以预防或减轻这种儿童哮喘动物模型的呼吸道炎症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Inhaled corticosteroids (ICS) are frequently used to treat persistent asthma in young children, however the safety and efficacy of this therapeutic modality during the first year of life is not known. We have previously reported that an exposure regimen of house dust mite (HDM) aerosol and ozone results in the development of airway hyperresponsiveness and eosinophilia in 6 month old infant rhesus monkeys. In the current study, we determined if ICS treatment can prevent or attenuate airways inflammation in this animal model of childhood asthma.