PHARMACOKINETICS OF NEW CEPHALOSPORINS
PHARMACOKINETICS OF NEW CEPHALOSPORINS
批准号:
7349813
负责人:
Robert E LANFORD
金额:
$0.04万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-05-01 至 2007-04-30
中文摘要
该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者(PI)可能从另一个NIH来源获得主要资金,因此可以在其他CRISP条目中表示。所列机构为中心,不一定是研究者所在机构。不断需要新的抗生素来治疗抗生素耐药生物体的感染。头孢菌素需要在黑猩猩中进行生物利用度测试,因为人类和黑猩猩中存在限制可用性的血清结合蛋白。因此,在黑猩猩中进行的药代动力学研究预测了启动人体试验的抗生素水平。拟议的实验将包括在2只体重相似的同性黑猩猩身上测试4种新的头孢菌素化合物。化合物将以0.5 mg/kg的剂量每两周IV给予。每次给药将包括以下采血时间:0或给药前即刻,15分钟,30分钟,1小时,2小时,4小时,8小时。24小时将检测血浆样本的药物水平,以确定这些新药的药代动力学。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. New antibiotics are constantly needed to treat infections with antibiotic resistant organisms. Cephalosporins need to be tested for bioavailability in chimpanzees, because there is a serum binding protein in humans and chimpanzees that limits availability. Thus, a pharmacokinetic study in chimpanzees predicts the level of antibiotic with which to initiate human trials. The proposed experiment will involve testing of 4 new cephalosporin compounds in 2 same-sex chimpanzees of similar weight. Compounds will be given IV every two weeks at a dose of 0.5 mg/kg. each dosing will involve the following blood sampling times; 0 or immediately prior to the dose, 15 min., 30 min., 1 hr., 2 hrs., 4 hrs., 8 hrs. and 24 hrs. Plasma samples will be tested for drug levels to determine the pharmacokinetics of these new drugs.
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会议论文
GBV-B: A SMALL PRIMATE MODEL FOR HEPATITIS C INFECTION
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批准号:8357644
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项目类别:
-
资助金额:$5.71万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
DEVELOPMENT OF A BABOON MODEL OF LIVER CANCER
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批准号:8357717
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项目类别:
-
资助金额:$3.56万
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财政年份:2011
-
负责人:Robert E LANFORD
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依托单位:
NIH-Owned Chimpanzee Research Resource at the SNPRC
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批准号:8727694
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项目类别:
-
资助金额:$0.0万
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财政年份:2011
-
负责人:Robert E LANFORD
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依托单位:
ANALYSIS OF CHIMPANZEE PK FOR GILEAD TLR AGONIST
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批准号:8357690
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项目类别:
-
资助金额:$2.41万
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财政年份:2011
-
负责人:Robert E LANFORD
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依托单位:
EFFICACY OF TLR7 AGONIST FOR CHRONIC HBV INFECTION IN CHIMPANZEES
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批准号:8357720
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项目类别:
-
资助金额:$4.1万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
CONVERSION OF IFN? NULL RESPONDER PHENOTYPE IN TO IFN RESPONDER PHENOTYPE
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批准号:8357716
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项目类别:
-
资助金额:$7.23万
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财政年份:2011
-
负责人:Robert E LANFORD
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依托单位:
The Innate Immune Response in the Marmoset Model of GBV-B Infections: A Surrogate
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批准号:8497598
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项目类别:
-
资助金额:$51.95万
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财政年份:2011
-
负责人:Robert E LANFORD
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依托单位:
The Innate Immune Response in the Marmoset Model of GBV-B Infections: A Surrogate
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批准号:8676647
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项目类别:
-
资助金额:$55.27万
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财政年份:2011
-
负责人:Robert E LANFORD
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依托单位:
MOLECULAR SWITCH VACCINES FOR BIODEFENSE, CANCER, AND INFECTIOUS DISEASE
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批准号:8357718
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项目类别:
-
资助金额:$3.09万
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财政年份:2011
-
负责人:Robert E LANFORD
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依托单位:
EVALUATION OF ANTIBODY IMMUNOTHERAPY FOR HCV IN CHIMPANZEES
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批准号:8357719
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项目类别:
-
资助金额:$3.66万
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财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
NIH-Owned Chimpanzee Research Resource at the SNPRC
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批准号:8500489
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项目类别:
-
资助金额:$65.0万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
The Innate Immune Response in the Marmoset Model of GBV-B Infections: A Surrogate
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批准号:8298145
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项目类别:
-
资助金额:$55.27万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
EFFICACY OF TLR7 AGONIST FOR CHRONIC HCV INFECTION IN CHIMPANZEES
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批准号:8357721
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项目类别:
-
资助金额:$5.06万
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财政年份:2011
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负责人:Robert E LANFORD
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依托单位:
SOUTHEASTERN COOPERATIVE HEPATITIS C RESEARCH GROUP
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批准号:8357641
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项目类别:
-
资助金额:$8.05万
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财政年份:2011
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负责人:Robert E LANFORD
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依托单位:
HCV ANTIVIRAL TESTING IN CHIMPANZEES
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批准号:8357679
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项目类别:
-
资助金额:$3.32万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
The Innate Immune Response in the Marmoset Model of GBV-B Infections: A Surrogate
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批准号:8162227
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项目类别:
-
资助金额:$54.75万
-
财政年份:2011
-
负责人:Robert E LANFORD
-
依托单位:
HCV ANTIVIRAL TESTING IN CHIMPANZEES
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批准号:8172698
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项目类别:
-
资助金额:$18.12万
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财政年份:2010
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负责人:Robert E LANFORD
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依托单位:
GBV-B: A SMALL PRIMATE MODEL FOR HEPATITIS C INFECTION
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批准号:8172642
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项目类别:
-
资助金额:$16.52万
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财政年份:2010
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负责人:Robert E LANFORD
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依托单位:
HCV CENTER STUDIES ON INFECTIOUS HCV
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批准号:8172651
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项目类别:
-
资助金额:$3.94万
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财政年份:2010
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负责人:Robert E LANFORD
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依托单位:
TLR LIGANDS IN GBV-B
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批准号:8172678
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项目类别:
-
资助金额:$10.66万
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财政年份:2010
-
负责人:Robert E LANFORD
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依托单位:
海外基金