A NOVEL APPROACH TO GERM-LINE PRESERVATION IN MACAQUES

猕猴种系保存的新方法

• 批准号: 7349697
• 负责人: STUART A MEYERS
• 金额: $ 4.97万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349697
• 关键词: NOVEL; APPROACH; GERM; LINE; PRESERVATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Spermatogonial stem cell transplantation may provide a method by which unique genotypes may be proliferated as well as a novel method to generate transgenic animals. Immediate objectives are to develop a successful method to isolate and enrich nonhuman primate germ line precursor cells and transplant spermatogonial stem cells from genetically unique male macaques to immunodeficient mice and recipient male macaques.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目的：精原干细胞移植可能提供一种独特的基因型可以增殖的方法，以及一种新的方法来产生转基因动物。近期目标是开发一种成功的方法，分离和富集非人灵长类动物生殖系前体细胞，并将精原干细胞从遗传独特的雄性猕猴移植到免疫缺陷小鼠和受体雄性猕猴。