A NOVEL APPROACH TO GERM-LINE PRESERVATION IN MACAQUES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Spermatogonial stem cell transplantation may provide a method by which unique genotypes may be proliferated as well as a novel method to generate transgenic animals. Immediate objectives are to develop a successful method to isolate and enrich nonhuman primate germ line precursor cells and transplant spermatogonial stem cells from genetically unique male macaques to immunodeficient mice and recipient male macaques.