3-D Transrectal Ultrasound with 2-D Arrays

采用 2-D 阵列的 3-D 经直肠超声

• 批准号: 7201773
• 负责人: JESSE T-P YEN
• 金额: $ 24.82万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-25 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7201773
• 关键词: 3-Dimensional; Address; Anatomy; Area; Biopsy; Brachytherapy; Canis familiaris; Clinical; Cold Therapy; Dependence; Development; Diagnosis; Digital Rectal Examination; Dimensions; Elevation; Exhibits; Gel; Goals; Image; Imagery; In Vitro; Malignant neoplasm of prostate; Medical; Methods; Needles; Noise; Numbers; Patients; Performance; Procedures; Prostate; Prostate-Specific Antigen; Research; Resolution; Resources; Sampling; Scanning; Scheme; Series; Shapes; Signal Transduction; Slice; System; Technology; Testing; Three-Dimensional Imaging; Time; Today; Transducers; Transrectal Ultrasound; Ultrasonic Transducer; Ultrasonics; Ultrasonography; United States National Institutes of Health; Water; concept; design; experience; improved; in vivo; innovation; novel; prototype; research study; skills; success; systems research; three dimensional structure; tissue phantom

DESCRIPTION (provided by applicant): The objective of this proposal is to develop a novel 3-D ultrasound and elastography system for in vivo imaging of the prostate. Typical transrectal ultrasound systems (TRUS) use a bi-plane probe to obtain two perpendicular B-scans, a sagittal view and longitudinal view. The probe is then manipulated to interrogate the entire prostate region. The results of such a scan can depend heavily on skill of the user since he/she must mentally integrate several images to gain an understanding of the three-dimensional anatomy. In addition, the success of ultrasound-guided biopsies can largely depend on the skill of the operator since the needle must be perfectly aligned within a single scan plane. However, a system capable of in vivo imaging of the prostate in three dimensions could help alleviate some of these problems and therefore show improved clinical value over today's commercial systems. Using an innovative row-column interconnect scheme, 256 x 256 5-10 MHz cylindrical 2-D arrays will be designed, prototyped and tested. This new system will allow for the synthesis of a fully sampled 2-D array capable of dynamic focusing in azimuth and elevation. Since our system will acquire a 3-D volume, new coronal views of the prostate will also be available. To demonstrate proof of concept, a prototype transducer will be integrated with a 64 channel ultrasound research system used to gather the necessary echo information needed to produce cylindrical 3- D volumes. A series of water tank and tissue phantom experiments will be performed to evaluate imaging performance in terms of resolution, contrast, and signal-to-noise ratio. Lastly, a small number of in vitro experiments of canine prostates will be done.

描述（由申请人提供）：该提案的目的是开发一种新型的3-D超声和弹性系统，用于前列腺的体内成像。典型的转直肠超声系统（TRUS）使用双平面探针获得两个垂直的B扫描，一个矢状视图和纵向视图。然后操纵探针以询问整个前列腺区域。这种扫描的结果可能在很大程度上取决于用户的技能，因为他/她必须在心理上整合几张图像才能了解三维解剖结构。此外，超声引导活检的成功很大程度上取决于操作员的技能，因为必须在单个扫描平面内完全对齐。但是，能够在三个维度上对前列腺进行体内成像的系统可以帮助减轻其中一些问题，因此比当今的商业系统显示出改善的临床价值。使用创新的行柱互连方案，将设计，原型和测试设计，原型和测试256 x 256 5-10 MHz圆柱2-D阵列。这个新系统将允许合成一个完全采样的二维阵列，能够在方位角和高程中进行动态聚焦。由于我们的系统将获得3D卷，因此还将提供前列腺的新冠状视图。为了证明概念证明，原型传感器将与64个通道超声研究系统集成，用于收集生产圆柱形3-d量所需的必要回声信息。将进行一系列水箱和组织幻影实验，以评估分辨率，对比度和信噪比的成像性能。最后，将进行少量的犬类前列腺体外实验。