Ultrasound stimulation of the baroreflex

超声波刺激压力反射

基本信息

批准号：
9297325
负责人：
JESSE T-P YEN
金额：
$ 24.75万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9297325
关键词：
Acute Affect Amplifiers Antihypertensive Agents Arteries Baroreflex Behavior Therapy Blood Pressure Blood Vessels Brain Bypass Canis familiaris Cardiovascular Diseases Cardiovascular Physiology Cessation of life Clinical Trials Computers Conscious Coupling Devices Diuretics Dose Energy-Generating Resources Exercise Failure Fiber Future Goals Guidelines Heart Heart Rate Heart failure Hypertension Impairment Ionizing radiation Kidney Kidney Diseases Lead Literature Location Maximum Tolerated Dose Measures Mechanics Medical Methods Modeling Monitor Morbidity - disease rate Myocardial Infarction Needles Neurons Operative Surgical Procedures Patients Pharmaceutical Preparations Pharmacologic Substance Pilot Projects Play Pressoreceptors Regulation Research Resistant Hypertension Risk Role Series Sinus Sodium Chloride Stretching Stroke Testing Transducers Ultrasonic Therapy Ultrasonography United States Vision Water Work blood pressure reduction blood pressure regulation blood pump cardiovascular risk factor carotid sinus constriction cost design experimental study follow-up hypertension treatment mortality multiple drug use neural stimulation normotensive novel pressure public health relevance radio frequency reduced food intake relating to nervous system response smoking cessation

项目摘要

DESCRIPTION (provided by applicant): Hypertension, most commonly referred to as "high blood pressure", is a medical condition in which there is an impaired ability of the kidneys to excrete salt and water. As a result of the rise in arterial pressure, the heart must work harder to pump blood through narrowed arteries and can lead to long-term damage to the heart and blood vessels. If this condition persists it increases the risk for stroke, heart attack, kidney disease nd heart failure. It is estimated to cause 1 in every 8 deaths worldwide. In cardiovascular physiology, the baroreflex, or baroreceptor reflex is one of the body's natural mechanisms for maintaining blood pressure. Ultrasound is an ideal energy source for non-invasive stimulation of the baroreceptors because it is does not have ionizing radiation and is low-cost. The goal of this proposal is to demonstrate the potential of using ultrasound as a therapy to treat hypertension by stimulating the carotid baroreceptors. A series of acute studies in a canine model is proposed to identify an appropriate range of stimulation parameters. The following specific aims are proposed to achieve this goal: 1. Design, fabricate, and test needle-shaped transduers operating at 1 MHz for accurate localization of ultrasound onto the carotid sinus, the location of the carotid baroreceptors. 2. Perform 20 acute canine studies to measure the blood pressure (BP) and heart rate (HR) responses to activation of the carotid baroreflex using various ultrasound stimulation parameters. 3. Perform studies in 4 conscious canines to measure the heart rate and blood pressure responses to more prolonged activation of the carotid baroreflex by ultrasound. The ultimate vision of this work is to develop a non-invasive wearable ultrasound therapy device capable of treating patients with treatment-resistant hypertension and possibly other sub-populations of patients suffering from varying degrees of hypertension.

描述（应用程序提供）：高血压，通常称为“高血压”，是一种医疗状况，肾脏能够受损的能力。由于动脉压的升高，心脏必须更加努力通过狭窄的动脉抽血，并可能导致对心脏和血管的长期损害。如果这种情况持续下去，它会增加中风，心脏病发作，肾脏疾病和心力衰竭的风险。据估计，它在全球每8例死亡中造成1人。在心血管生理学中，压力反射或压力感受器反射是人体维持血压的自然机制之一。超声是无创刺激压力感受器的理想能源，因为它没有电离辐射，并且是低成本的。该提案的目的是证明使用超声用作通过刺激颈动脉压力受体治疗高血压的疗法的潜力。提出了一系列在犬模型中的急性研究，以识别适当的刺激参数。提出了以下特定目的来实现此目标：1。设计，制造和测试针状换能器以1 MHz的形式进行，以将超声定位在颈动脉窦（Harotid Sinus）上，这是颈动脉压力体受体的位置。 2。使用各种超声刺激参数进行20次急性犬研究，以测量血压（BP）和心率（HR）对颈动脉压力反射的反应。 3.在4个有意识的犬类中进行研究，以测量超声对颈动脉压力反射的更长激活的心率和血压反应。这项工作的最终视觉是开发一种非侵入性可穿戴超声治疗装置，能够治疗患有耐药性高血压的患者以及患有不同高度高度的患者的其他可能的亚人群。