Ultrasound stimulation of the baroreflex

超声波刺激压力反射

• 批准号: 9091229
• 负责人: JESSE T-P YEN
• 金额: $ 19.39万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9091229
• 关键词: Acute; Affect; Amplifiers; Antihypertensive Agents; Arteries; Baroreflex; Behavior Therapy; Blood Pressure; Blood Vessels; Brain; Bypass; Canis familiaris; Cardiovascular Diseases; Cardiovascular Physiology; Cessation of life; Clinical Trials; Computers; Conscious; Coupling; Devices; Diuretics; Dose; Energy-Generating Resources; Exercise; Failure; Fiber; Future; Goals; Guidelines; Heart; Heart Rate; Heart failure; Hypertension; Hypotension; Ionizing radiation; Kidney; Kidney Diseases; Lead; Literature; Location; Maximum Tolerated Dose; Measures; Mechanics; Medical; Methods; Modeling; Monitor; Morbidity - disease rate; Myocardial Infarction; Needles; Neurons; Operative Surgical Procedures; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Pilot Projects; Play; Pressoreceptors; Regulation; Research; Resistant Hypertension; Risk; Risk Factors; Role; Series; Shapes; Sinus; Sodium Chloride; Stretching; Stroke; Testing; Transducers; Ultrasonic Therapy; Ultrasonography; United States; Vision; Water; Work; base; blood pressure reduction; blood pressure regulation; blood pump; carotid sinus; constriction; cost; design; follow-up; hypertension treatment; mortality; multiple drug use; neural stimulation; normotensive; novel; patient population; pressure; public health relevance; radio frequency; reduced food intake; relating to nervous system; research study; response; smoking cessation

 DESCRIPTION (provided by applicant): Hypertension, most commonly referred to as "high blood pressure", is a medical condition in which there is an impaired ability of the kidneys to excrete salt and water. As a result of the rise in arterial pressure, the heart must work harder to pump blood through narrowed arteries and can lead to long-term damage to the heart and blood vessels. If this condition persists it increases the risk for stroke, heart attack, kidney disease nd heart failure. It is estimated to cause 1 in every 8 deaths worldwide. In cardiovascular physiology, the baroreflex, or baroreceptor reflex is one of the body's natural mechanisms for maintaining blood pressure. Ultrasound is an ideal energy source for non-invasive stimulation of the baroreceptors because it is does not have ionizing radiation and is low-cost. The goal of this proposal is to demonstrate the potential of using ultrasound as a therapy to treat hypertension by stimulating the carotid baroreceptors. A series of acute studies in a canine model is proposed to identify an appropriate range of stimulation parameters. The following specific aims are proposed to achieve this goal: 1. Design, fabricate, and test needle-shaped transduers operating at 1 MHz for accurate localization of ultrasound onto the carotid sinus, the location of the carotid baroreceptors. 2. Perform 20 acute canine studies to measure the blood pressure (BP) and heart rate (HR) responses to activation of the carotid baroreflex using various ultrasound stimulation parameters. 3. Perform studies in 4 conscious canines to measure the heart rate and blood pressure responses to more prolonged activation of the carotid baroreflex by ultrasound. The ultimate vision of this work is to develop a non-invasive wearable ultrasound therapy device capable of treating patients with treatment-resistant hypertension and possibly other sub-populations of patients suffering from varying degrees of hypertension.

 描述（由申请人提供）：高血压，最常被称为“高血压”，是一种肾脏排泄盐和水的能力受损的医学病症。由于动脉压升高，心脏必须更加努力地工作， 通过狭窄的动脉泵血，可能导致心脏和血管的长期损害。如果这种情况持续下去，它会增加中风、心脏病发作、肾脏疾病和心力衰竭的风险。据估计，全世界每8例死亡中就有1例是由它造成的。在心血管生理学中，压力感受器反射或压力感受器反射是人体维持血压的自然机制之一。超声波是一种理想的能量来源，用于压力感受器的非侵入性刺激，因为它不具有电离辐射并且成本低。本提案的目的是证明使用超声波作为通过刺激颈动脉压力感受器治疗高血压的疗法的潜力。提出在犬模型中进行一系列急性研究，以确定适当的刺激参数范围。为实现这一目标，提出了以下具体目标：1.设计、制造和测试在1 MHz下工作的针形换能器，用于将超声准确定位到颈动脉窦（颈动脉压力感受器的位置）。2.进行20项急性犬研究，以测量血压（BP）和心率（HR）对使用各种超声刺激参数激活颈动脉压力感受器反射的反应。3.在4只清醒的犬中进行研究，以测量心率和血压对超声更长时间激活颈动脉压力感受器反射的反应。这项工作的最终愿景是开发一种非侵入性的可穿戴超声治疗设备，能够治疗难治性高血压患者以及可能患有不同程度高血压的其他亚群患者。