DEVELOPMENT SMALL ANIMAL DIGITAL SUBTRACTION ANGIOGRAPHY

开发小动物数字减影血管造影

• 批准号: 7358255
• 负责人: MING DE LIN
• 金额: $ 1.54万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358255
• 关键词: DEVELOPMENT; SMALL; ANIMAL; DIGITAL; SUBTRACTION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: We will explore the use of several different K emission X-ray sources (W, Mo, Rh) to improve the contrast-to-noise for small animal digital subtraction angiography. Use of a K emitter will improve contrast to noise by: 1) flux production of the K emitters is much more efficient at low energies than Bremstrhalung; 2) the quantum detection efficiency of the detector phosphors is much higher at lower energies (detecting phosphors must be thin to limit resolution degradation from light scatter); and 3) photoelectric absorption differences between soft tissue, calcification and iodine/gadolinium (potential vascular contrast agents) increase at lower energy. Specific Aim 2: Based on simulation results described in Specific Aim 1, we will enhance our current micro-X-ray system for small animal digital subtraction angiography.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。具体目标1：我们将探索使用几种不同的K发射x射线源（W, Mo, Rh）来提高小动物数字减影血管造影术的噪比。使用K发射器将通过以下方式改善噪声的对比度：1)在低能量下，K发射器的通量产生比轫致辐射效率高得多；2)在较低能量下，探测荧光粉的量子探测效率要高得多（探测荧光粉必须很薄，以限制光散射导致的分辨率下降）；3)软组织、钙化和碘/钆（潜在血管造影剂）之间的光电吸收差异在能量较低时增大。具体目标2：基于具体目标1中描述的模拟结果，我们将改进目前用于小动物数字减影血管造影的微x射线系统。