DEVELOPMENT SMALL ANIMAL DIGITAL SUBTRACTION ANGIOGRAPHY

开发小动物数字减影血管造影

• 批准号: 7601135
• 负责人: MING DE LIN
• 金额: $ 1.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601135
• 关键词: Animals; Blood Vessels; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Detection; Development; Digital Subtraction Angiography; Funding; Gadolinium; Grant; Institution; Iodine; Noise; Production; Research; Research Personnel; Resolution; Resources; Roentgen Rays; Source; System; United States National Institutes of Health; absorption; base; calcification; detector; improved; light scattering; quantum; simulation; soft tissue

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: We will explore the use of several different K emission X-ray sources (W, Mo, Rh) to improve the contrast-to-noise for small animal digital subtraction angiography. Use of a K emitter will improve contrast to noise by: 1) flux production of the K emitters is much more efficient at low energies than Bremstrhalung; 2) the quantum detection efficiency of the detector phosphors is much higher at lower energies (detecting phosphors must be thin to limit resolution degradation from light scatter); and 3) photoelectric absorption differences between soft tissue, calcification and iodine/gadolinium (potential vascular contrast agents) increase at lower energy. Specific Aim 2: Based on simulation results described in Specific Aim 1, we will enhance our current micro-X-ray system for small animal digital subtraction angiography.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 具体目标 1：我们将探索使用几种不同的 K 发射 X 射线源（W、Mo、Rh）来提高小动物数字减影血管造影的噪声对比度。使用 K 发射器将通过以下方式改善噪声对比度： 1) K 发射器的通量产生在低能量下比轫致辐射更有效； 2) 检测器荧光粉的量子检测效率在较低能量下要高得多（检测荧光粉必须很薄，以限制光散射引起的分辨率下降）； 3) 软组织、钙化和碘/钆（潜在血管造影剂）之间的光电吸收差异在较低能量下增加。 具体目标 2：根据具体目标 1 中描述的模拟结果，我们将增强当前用于小动物数字减影血管造影的微 X 射线系统。