MOTILITY OF LIVE CELLS QUANTIFIED BY FOURIER PHASE MICROSCOPY

通过傅里叶相显微镜量化活细胞的运动性

• 批准号: 7357929
• 负责人: Gabriela K Popescu
• 金额: $ 3.05万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357929
• 关键词: microscopy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using the ability of Fourier phase microscopy to retrieve two-dimensional phase shift information from transparent structures with high transverse resolution and low-noise, motility of epithelial cancer cells has been quantified. The results in terms of the mean squared displacements suggest that the nature of cell motion is superdiffusive for cells at various stages of their life cycle. However, the effective diffusion coefficient for mitotic cells is approximately double that of non-mitotic cells.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。利用傅里叶相位显微镜的能力，检索二维相移信息透明结构具有高横向分辨率和低噪声，上皮癌细胞的运动性已被量化。的均方位移方面的结果表明，细胞运动的性质是superdiffusive细胞在其生命周期的各个阶段。然而，有丝分裂细胞的有效扩散系数大约是非有丝分裂细胞的两倍。