MOTILITY OF LIVE CELLS QUANTIFIED BY FOURIER PHASE MICROSCOPY

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using the ability of Fourier phase microscopy to retrieve two-dimensional phase shift information from transparent structures with high transverse resolution and low-noise, motility of epithelial cancer cells has been quantified. The results in terms of the mean squared displacements suggest that the nature of cell motion is superdiffusive for cells at various stages of their life cycle. However, the effective diffusion coefficient for mitotic cells is approximately double that of non-mitotic cells.