IMPROVED PERFORMANCE OF 4-PI MICROSCOPY USING HILBERT PHASE MICROSCOPY

使用希尔伯特相差显微镜提高 4-PI 显微镜的性能

• 批准号: 7600910
• 负责人: Gabriela K Popescu
• 金额: $ 1.17万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7600910
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Imaging Techniques; Institution; Microscopy; Performance; Phase; Refractive Indices; Research; Research Personnel; Resolution; Resources; Sampling; Source; Structure; Tissues; United States National Institutes of Health; cellular imaging; improved; indexing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 4-Pi microscopy has become a powerful high-resolution technique for imaging cells and tissues. However, refractive index inhomogeneities present in these structures limit its performance. Our preliminary studies show that, our Hilbert phase microscopy can provide the refractive index information about the sample. This will help improve the tissue index matching and, thus, the overall 4-Pi microscopy performance.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 4-PI显微镜已经成为一种强大的高分辨率细胞和组织成像技术。然而，这些结构中存在的折射率不均匀限制了它的性能。我们的初步研究表明，我们的希尔伯特位相显微镜可以提供样品的折射率信息。这将有助于改进组织索引匹配，从而改善整体4-PI显微镜性能。