CYCLODEXTRIN-ENHANCED FLUORESCENCE OF POLYAROMATIC HYDROCARBONS

环糊精增强的多环芳烃荧光

• 批准号: 7373154
• 负责人: DAVID RUSAK
• 金额: $ 0.14万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7373154
• 关键词: CYCLODEXTRIN; ENHANCED; FLUORESCENCE; POLYAROMATIC; HYDROCARBONS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The enhancement of fluorescence of aqueous solutions of several polyaromatic hydrocarbons (PAH) by complexation with cyclodextrin is investigated. Specifically, we are interested in PAH of different molecular size and solubility complexed with alpha and beta cyclodextrin. Quenching of fluorescence will be assessed by generation of Stern-Volmer plots for both the complexes and the free PAH, and fluorescence lifetimes for both the complexes and free PAH will be measured in order to show to what extent the shielding of the fluorophore from the solvent, thought to be the primary mechanism of fluorescence enhancement by cyclodextrin complexation, accounts for changes in the fluorescence quantum efficiencies or the fluorescence lifetimes.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。研究了环糊精对几种多芳烃（PAH）水溶液的荧光增强作用。具体来说，我们对不同分子大小和溶解度的多环芳烃与α和β环糊精络合感兴趣。荧光猝灭将通过生成配合物和游离多环芳烃的Stern-Volmer图来评估，并测量配合物和游离多环芳烃的荧光寿命，以显示荧光团对溶剂的屏蔽在多大程度上解释了荧光量子效率或荧光寿命的变化，这被认为是环糊精络合增强荧光的主要机制。