Growth Form and Function: the Mathematics of 3D Tissue Morphogenesis and Regenerative Medicine

生长形式和功能：3D 组织形态发生和再生医学的数学

• 批准号: BB/D008522/1
• 负责人: John King
• 金额: $ 150.88万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FD008522%2F1
• 关键词: Growth; Form; Function; Mathematics; 3D

Recent advances in regenerative medicine promise major breakthroughs for healthcare and in the understanding of cell and tissue function. Moreover, the field provokes a host of important systems-biology questions that raise formidable challenges at the forefront of current developments in mathematics. This proposal seeks to capitalise on areas of world-class expertise within the University of Nottingham (in mathematical medicine, cell signalling, tissue engineering and stem-cell biology) to establish an internationally-leading group equipped to address these challenges. The investigations that the research programme will pursue will seek to further the understanding of the mechanisms by which cells communicate with one another, and of how this communication influences both the behaviour of individual cells and the manner in which aggregates of cells assemble and function. The results will have implications for a wide range of topics of great current importance, including for stem-cell behaviour and for the generation of gut tissue and of bone. The integration of this work within the Centre for Regenerative Medicine at Nottingham should generate enormous added value, producing powerful computational tools whose range of application, for example in providing insight into experimentally or ethically inaccessible in vivo systems, will be immense.

再生医学的最新进展有望为医疗保健以及对细胞和组织功能的理解带来重大突破。此外，该领域引发了一系列重要的系统生物学问题，这些问题在当前数学发展的前沿提出了艰巨的挑战。该提案旨在利用诺丁汉大学（数学医学，细胞信号，组织工程和干细胞生物学）的世界级专业知识领域，建立一个国际领先的团队，以应对这些挑战。该研究计划将进行的调查将寻求进一步了解细胞相互交流的机制，以及这种交流如何影响单个细胞的行为以及细胞聚集和功能的方式。这些结果将对当前非常重要的广泛主题产生影响，包括干细胞行为以及肠道组织和骨骼的生成。整合这项工作在再生医学中心在诺丁汉应产生巨大的附加值，产生强大的计算工具，其应用范围，例如在提供深入了解实验或伦理上无法进入体内系统，将是巨大的。

项目成果

Measuremen t of real-time changes in intracellular cAMP levels in HEK293 cells in response to adenosine A2receptor activation using a GlosensorTM assay

使用 GlosensorTM 测定法测量 HEK293 细胞响应腺苷 A2 受体激活的细胞内 cAMP 水平的实时变化

• 发表时间: 2009
• 期刊: Proceedings of the BPS
• 作者: Alcock, J

Modeling and simulation of inverse agonism dynamics.

逆激动动力学的建模和模拟。

• DOI: 10.1016/b978-0-12-381296-4.00029-4
• 发表时间: 2010
• 期刊: Methods in enzymology
• 作者: Bridge LJ

Techniques for analysing pattern formation in populations of stem cells and their progeny.

• DOI: 10.1186/1471-2105-12-396
• 发表时间: 2011-10-12
• 期刊: BMC bioinformatics
• 影响因子: 3
• 作者: Fozard JA;Kirkham GR;Buttery LD;King JR;Jensen OE;Byrne HM
• 通讯作者: Byrne HM

Identification Of An Allosteric Site On The Adenosine A2B Receptor With The Fluorescent Ligand ABEA-XBY630

用荧光配体 ABEA-XBY630 鉴定腺苷 A2B 受体上的变构位点

• 发表时间: 2011
• 期刊: Proceedings of the BPS
• 作者: Alcock, J

Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.

• DOI: 10.1111/j.1476-5381.2009.00488.x
• 发表时间: 2010-02
• 期刊: British journal of pharmacology
• 影响因子: 7.3
• 作者: Baker JG;Middleton R;Adams L;May LT;Briddon SJ;Kellam B;Hill SJ
• 通讯作者: Hill SJ