Growth Form and Function: the Mathematics of 3D Tissue Morphogenesis and Regenerative Medicine

点击翻译按钮获取中文摘要

Recent advances in regenerative medicine promise major breakthroughs for healthcare and in the understanding of cell and tissue function. Moreover, the field provokes a host of important systems-biology questions that raise formidable challenges at the forefront of current developments in mathematics. This proposal seeks to capitalise on areas of world-class expertise within the University of Nottingham (in mathematical medicine, cell signalling, tissue engineering and stem-cell biology) to establish an internationally-leading group equipped to address these challenges. The investigations that the research programme will pursue will seek to further the understanding of the mechanisms by which cells communicate with one another, and of how this communication influences both the behaviour of individual cells and the manner in which aggregates of cells assemble and function. The results will have implications for a wide range of topics of great current importance, including for stem-cell behaviour and for the generation of gut tissue and of bone. The integration of this work within the Centre for Regenerative Medicine at Nottingham should generate enormous added value, producing powerful computational tools whose range of application, for example in providing insight into experimentally or ethically inaccessible in vivo systems, will be immense.