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Bridging the Gaps: Systems-level approaches to antimicrobial resistance

弥合差距：解决抗菌素耐药性的系统级方法

基本信息

批准号：
EP/M027333/1
负责人：
John King
金额：
$ 62.59万
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FM027333%2F1
关键词：
Bridging Gaps Systems level approaches

项目摘要

The problem of antimicrobial resistance (AMR) is an increasing challenge, not only in the context of healthcare but also in, for example, food safety and agriculture. The prevalence of resistant bugs such as MRSA has received widespread media coverage and the problems relating to resistance are now more widely recognised than ever before, as is the importance of developing new approaches, particularly given the increase in issues associated with multidrug resistant species. The current proposal seeks to drawn on wide-ranging applicable expertise in engineering and the physical sciences that, in collaboration with biological-science researchers, clinicians and industry, offers hitherto unexploited opportunities to contribute significantly to addressing these very significant challenges.We shall accordingly deliver a programme of activities that promotes new interdisciplinary collaborations across traditional boundaries between engineering, the physical sciences and the biological sciences. The University of Nottingham has an outstanding history of such discipline-bridging activities, as well as of research relevant to AMR, and will bring this experience to bear upon the challenge of AMR. The primary mechanism for promoting new research collaborations will be that of themed Sandpits, building on the success of the Mathematics-in-Medicine Study Groups pioneered by the University in 2000 (and subsequently spawning the Mathematics-in-the-Plant-Sciences Study Groups and others). In these, presenters from the biological sciences, clinical medicine or industry will describe issues that could benefit from new approaches drawn from engineering and the physical sciences; intensive brain-storming work on these topics will identify the skills needed and establish the relevant cross-disciplinary teams; seed funding will then be provided for the most promising projects identified. While the process is now well-established, the outcomes of such workshops are very far from predictable and the aggregation of the range of disciplines outlined above should ensure that innovative approaches come to the fore. Other mechanisms will include Challenge Days (modifying the successful approach of the Industry Challenge Days held by the Business School to ensure that research developments align with the needs of potential end users), discipline-hopping secondments, speed-networking sessions, cross-disciplinary workshops (focussing on specific methodologies, to enhance further the opportunities for identifying potential crossovers between research fields) and annual showcases in the form of a launch event and a concluding 'forward-look' workshop. These activities will be augmented by a Visiting-Scholar programme whereby leading experts in complementary areas will contribute their expertise to the initiative.Funding from the programme will be assigned in competition to multidisciplinary projects judged on their research excellence and their capacity to contribute to addressing AMR challenges. The programme's Strategy Group will be responsible for assessing applications and for monitoring progress; the activities outlined above are specifically designed (in particular by bringing together researchers from diverse disciplines) to ensure that the research ideas developed are highly innovative and that the associated projects have the required mix of research expertise. The programme will be very explicitly outward-facing, drawing extensively on input from clinicians, industrialists and other potential end users, as well as interacting with complementary research elsewhere. In combination with the excellence and innovation of the research developed, such collaborations will ensure the sustainability of the initiative.

抗生素耐药性（AMR）问题是一个日益严峻的挑战，不仅在医疗保健领域，而且在食品安全和农业等领域。耐药性细菌（如MRSA）的流行得到了媒体的广泛报道，与耐药性相关的问题现在比以往任何时候都得到了更广泛的认识，开发新方法的重要性也是如此，特别是考虑到与多药耐药物种相关的问题增加。目前的建议旨在利用工程和物理科学领域广泛适用的专业知识，与生物科学研究人员、临床医生和工业界合作，为应对这些非常重大的挑战提供迄今尚未利用的机会。我们将相应地提供一个活动计划，促进跨越工程、物理科学和生物科学。诺丁汉大学在跨学科活动以及AMR相关研究方面有着杰出的历史，并将把这一经验用于应对AMR的挑战。促进新的研究合作的主要机制将是主题沙坑，建立在2000年大学开创的数学医学研究小组的成功基础上（随后催生了数学植物科学研究小组等）。在这些会议上，来自生物科学、临床医学或工业界的演讲者将描述可以从工程和物理科学的新方法中受益的问题;关于这些主题的密集头脑风暴工作将确定所需的技能并建立相关的跨学科团队;然后将为确定的最有前途的项目提供种子资金。虽然这一进程现已确立，但这些讲习班的成果远非可预测，将上述一系列学科结合起来应能确保创新办法脱颖而出。其他机制将包括挑战日（修改商学院举办的行业挑战日的成功方法，以确保研究开发与潜在最终用户的需求保持一致），跨学科借调，快速网络会议，跨学科研讨会（侧重于具体方法，进一步增加确定研究领域之间潜在交叉的机会），并以启动活动和总结性“前瞻性”研讨会的形式举办年度展示会。这些活动将通过访问学者计划得到加强，互补领域的领先专家将为该倡议贡献他们的专业知识，该计划的资金将通过竞争分配给多学科项目，这些项目将根据其研究卓越性及其为应对AMR挑战做出贡献的能力进行评判。该方案的战略小组将负责评估申请和监测进展情况;上述活动是专门设计的（特别是通过汇集不同学科的研究人员），以确保所提出的研究想法具有高度创新性，相关项目具有所需的研究专门知识组合。该计划将非常明确地面向外部，广泛借鉴临床医生，工业家和其他潜在最终用户的投入，并与其他地方的互补研究互动。这种合作与所开展研究的卓越性和创新性相结合，将确保该倡议的可持续性。