Quantitative and contextual modelling of transcriptional responses to auxin

生长素转录反应的定量和情境建模

基本信息

  • 批准号:
    BB/F008511/1
  • 负责人:
  • 金额:
    $ 13.45万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2008
  • 资助国家:
    英国
  • 起止时间:
    2008 至 无数据
  • 项目状态:
    已结题

项目摘要

Auxin is a plant hormone that plays an important role in many, very different aspects of plant growth and development. For example, on one hand auxin regulates the pattern in which leaves emerge from the growing shoot tip, while on the other it mediates environmental responses such as the bending growth observed in shoots growing towards a light source. Because auxin is integral to so much of plant development, a knowledge of how auxin works is absolutely fundamental to our ability both to understand how plants grow and to improve important crop traits. Although it is unclear how auxin, a small and simple molecule, is able to regulate such a diversity of processes, it is known that changes in gene expression are important and that several hundred genes are either turned on or off in response to auxin. Work from several labs has established a network of signalling proteins whose complex interactions translate increases in auxin levels within a cell into gene expression changes. However, this model of auxin signalling is generic and contains several gaps which mean that in most cases it offers only a theoretical basis for understanding how auxin operates throughout the plant. We can identify the new information required to remedy this situation and with this work we intend to use newly available techniques to obtain these data and correct the deficiencies of the current model. The complexity of the interactions in this auxin response system mean that the data that describe it are similarly complex, and therefore we need to adopt a new approach for analysing the information that we will gather in which we build mathematical models that describe the functioning of the system. These models can then be used to test our predictions of how the auxin response system works, generate new hypotheses about its functioning, and ultimately tell us if we have understood its essential details. This higher level of understanding of auxin action will be useful to a number of groups, including plant biologists, crop scientists, and scientists studying similarly complex signalling mechanisms in other organisms.
生长素是一种植物激素,在植物生长和发育的许多非常不同的方面发挥重要作用。例如,一方面,生长素调节叶片从生长的茎尖出现的模式,而另一方面,它介导环境反应,例如在朝向光源生长的茎中观察到的弯曲生长。因为生长素是植物发育的组成部分,所以了解生长素的作用方式对于我们理解植物如何生长和改善重要作物性状的能力至关重要。虽然目前还不清楚生长素,一个小而简单的分子,是如何能够调节这样一个过程的多样性,它是已知的,基因表达的变化是重要的,几百个基因或打开或关闭,以响应生长素。几个实验室的工作已经建立了一个信号蛋白网络,这些信号蛋白的复杂相互作用将细胞内生长素水平的增加转化为基因表达的变化。然而,这种生长素信号模型是通用的,包含几个空白,这意味着在大多数情况下,它只提供了一个理论基础,了解生长素如何在整个植物中运作。我们可以确定补救这种情况所需的新信息,通过这项工作,我们打算使用新的可用技术来获得这些数据,并纠正当前模型的缺陷。在这个生长素反应系统中相互作用的复杂性意味着描述它的数据也同样复杂,因此我们需要采用一种新的方法来分析我们将收集的信息,我们将建立描述系统功能的数学模型。然后,这些模型可以用来测试我们对生长素反应系统如何工作的预测,产生关于其功能的新假设,并最终告诉我们是否已经了解其基本细节。这种对生长素作用的更高水平的理解将对许多团体有用,包括植物生物学家,作物科学家和研究其他生物中类似复杂信号机制的科学家。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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John King其他文献

The goede vrouw of Mana-ha-ta at home and in society, 1609-1760
Mana-ha-ta 的 goede vrouw 在家庭和社会中,1609-1760 年
  • DOI:
    10.1093/oso/9780199595037.003.0005
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    1.8
  • 作者:
    Van Rensselaer;John King
  • 通讯作者:
    John King
Was the Lanyu pig independently domesticated in the Philippines? A meta-analysis review on the prehistoric expansion of the unique Lanyu pigs
兰屿猪是菲律宾独立驯养的吗?
Chromatin Organization and Phase Separation of Histones
  • DOI:
    10.1016/j.bpj.2020.11.1771
  • 发表时间:
    2021-02-12
  • 期刊:
  • 影响因子:
  • 作者:
    Anisha Shakya;John King
  • 通讯作者:
    John King
Temporal trends of Aroclor 1268 in the Taunton River estuary: Evidence of early production, use and release to the environment
  • DOI:
    10.1016/j.marpolbul.2006.05.019
  • 发表时间:
    2006-09-01
  • 期刊:
  • 影响因子:
  • 作者:
    Mark G. Cantwell;John King;R.M. Burgess
  • 通讯作者:
    R.M. Burgess
49. Idiopathic intracranial hypertension
  • DOI:
    10.1016/j.jocn.2010.07.050
  • 发表时间:
    2010-12-01
  • 期刊:
  • 影响因子:
  • 作者:
    John King
  • 通讯作者:
    John King

John King的其他文献

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{{ truncateString('John King', 18)}}的其他基金

The North Atlantic Climate System Integrated Study (ACSIS) - 1 year extension
北大西洋气候系统综合研究 (ACSIS) - 延长 1 年
  • 批准号:
    NE/V013246/1
  • 财政年份:
    2021
  • 资助金额:
    $ 13.45万
  • 项目类别:
    Research Grant
The North Atlantic Climate System Integrated Study
北大西洋气候系统综合研究
  • 批准号:
    NE/N018028/1
  • 财政年份:
    2016
  • 资助金额:
    $ 13.45万
  • 项目类别:
    Research Grant
Bridging the Gaps: Systems-level approaches to antimicrobial resistance
弥合差距:解决抗菌素耐药性的系统级方法
  • 批准号:
    EP/M027333/1
  • 财政年份:
    2015
  • 资助金额:
    $ 13.45万
  • 项目类别:
    Research Grant
Collaborative Research: A 650,000 year record of hydroclimate in the Western Pacific Warm Pool: Scientific Drilling at Lake Towuti, Indonesia
合作研究:西太平洋暖池 65 万年水文气候记录:印度尼西亚托乌提湖科学钻探
  • 批准号:
    1401733
  • 财政年份:
    2014
  • 资助金额:
    $ 13.45万
  • 项目类别:
    Continuing Grant
Systems biology of the butanol-producing Clostridium acetobutylicum: new source of biofuel and chemicals/COSMIC2
生产丁醇的丙酮丁醇梭菌的系统生物学:生物燃料和化学品的新来源/COSMIC2
  • 批准号:
    BB/I004513/1
  • 财政年份:
    2010
  • 资助金额:
    $ 13.45万
  • 项目类别:
    Research Grant
Orographic Flows and the Climate of the Antarctic Peninsula (OFCAP)
南极半岛的地形流和气候 (OFCAP)
  • 批准号:
    NE/G014124/1
  • 财政年份:
    2009
  • 资助金额:
    $ 13.45万
  • 项目类别:
    Research Grant
SysMO: Systems Biology of Clostridium acetobutylicum - a possible answer to dwindling crude oil reserves.
SysMO:丙酮丁醇梭菌的系统生物学 - 原油储量减少的可能答案。
  • 批准号:
    BB/F003382/1
  • 财政年份:
    2007
  • 资助金额:
    $ 13.45万
  • 项目类别:
    Research Grant
Growth Form and Function: the Mathematics of 3D Tissue Morphogenesis and Regenerative Medicine
生长形式和功能:3D 组织形态发生和再生医学的数学
  • 批准号:
    BB/D008522/1
  • 财政年份:
    2006
  • 资助金额:
    $ 13.45万
  • 项目类别:
    Research Grant
Collaborative Research: The Lake Malawi Drilling Project - A long, high-resolution record of abrupt climate change in the southern tropics of East Africa
合作研究:马拉维湖钻探项目——东非南部热带气候突变的长期高分辨率记录
  • 批准号:
    0602346
  • 财政年份:
    2006
  • 资助金额:
    $ 13.45万
  • 项目类别:
    Standard Grant
Collaborative Research: High-Resolution, Low-Latitude Paleoclimatology from Newly Acquired Sediment Drill Cores from Lake Bosumtwi, Ghana"
合作研究:来自加纳博苏姆特维湖新获得的沉积物钻芯的高分辨率、低纬度古气候学"
  • 批准号:
    0602319
  • 财政年份:
    2006
  • 资助金额:
    $ 13.45万
  • 项目类别:
    Standard Grant

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