Structural basis of syndecan-4 activation by fibronectin

纤连蛋白激活 syndecan-4 的结构基础

• 批准号: BB/D008719/1
• 负责人: Martin Humphries
• 金额: $ 29.51万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FD008719%2F1
• 关键词: Structural; basis; syndecan; activation; fibronectin

Sticking, or adhesion, of cells, either to other cells or to the tissue proteins that surround them in the body, is a vital part of multicellular life. Adhesion is needed for holding the body together and for keeping cells in the right place. During the course of many diseases, adhesion is used by cells to move abnormally throughout the body. Consequently, drugs that control adhesion might be useful for treating cardiovascular diseases, asthma, cancer, bacterial infections and ulcers. The work proposed in this application uses a combination of techniques to solve the structure of some important adhesive proteins. If successful, the work will help us to understand more about how the molecules involved in adhesion work. It might also suggest ways to design drugs to control adhesion or to engineer tissues.

细胞与其他细胞或体内围绕它们的组织蛋白的粘附或粘附是多细胞生命的重要组成部分。需要粘附力来将身体固定在一起并将细胞保持在正确的位置。在许多疾病的过程中，细胞利用粘附在全身异常移动。因此，控制粘连的药物可能有助于治疗心血管疾病、哮喘、癌症、细菌感染和溃疡。本申请中提出的工作使用多种技术的组合来解决一些重要的粘附蛋白的结构。如果成功，这项工作将帮助我们更多地了解参与粘附的分子是如何工作的。它还可能提出设计药物来控制粘附或改造组织的方法。

项目成果

The alternatively spliced type III connecting segment of fibronectin is a zinc-binding module.

• DOI: 10.1016/j.matbio.2007.04.001
• 发表时间: 2007-07
• 期刊: Matrix biology : journal of the International Society for Matrix Biology
• 作者: Askari JA;Thornton DJ;Humphries JD;Buckley PA;Humphries MJ
• 通讯作者: Humphries MJ

Definition of the fibroblast adhesome using multiplexed proximity biotinylation

• DOI: 10.1101/2020.01.24.918458
• 发表时间: 2020-01
• 期刊: bioRxiv
• 作者: Megan R. Chastney;C. Lawless;J. Humphries;Stacey Warwood;Matthew C. Jones;David Knight;Claus Jørgensen;M. Humphries

Multiplexed Proximity Biotinylation Coupled to Mass Spectrometry for Defining Integrin Adhesion Complexes.

• DOI: 10.1002/cpcb.113
• 发表时间: 2020-09-01
• 期刊: Current protocols in cell biology
• 作者: Chastney, Megan R;Lawless, Craig;Humphries, Martin J
• 通讯作者: Humphries, Martin J