BETA CELL OXYGEN CONSUMPTION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mitochondria play a key role in the regulation of insulin secretion from pancreatic islet cells, and oxygen consumption in response to fuel secretagogues represents an important marker of mitochondrial metabolism. Oscillatory metabolism, including oscillations in oxygen consumption, is believed to underline pulsatile insulin output from the beta cells. Oscillatory insulin secretion is important, as suggested by its loss in type 2 diabetic patients. Currently, oscillatory glycolysis via phosphofructokinas (PFK) has been considered the main system responsible for generation of oscillatory insulin secretion.