PLASMA MEMBRANE ELECTRON TRANSPORT AS A CONNECTOR OF THE BETA CELL METABOLIC CIRC

质膜电子传输作为 β 细胞代谢 CIRC 的连接器

• 批准号: 8074143
• 负责人: Emma Heart
• 金额: $ 23.3万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8074143
• 关键词: Accounting; Adenovirus Vector; Affect; Aftercare; Antioxidants; B-Lymphocytes; Beta Cell; Biochemical Pathway; Cell membrane; Cell physiology; Cells; Coenzyme Q10; Consensus; Couples; Coupling; Custom; Cytoplasm; Data; Dose; Drug Delivery Systems; Electron Transport; Electron Transport Pathway; Electrons; Glucose; Image; Insulin; Islets of Langerhans; Lead; Mediating; Mediator of activation protein; Metabolic; Metabolic Pathway; Metabolism; Mitochondria; Modeling; Molecular; NADH; NADP; NQO1 gene; Non-Insulin-Dependent Diabetes Mellitus; Normal Cell; Orthovanadate; Output; Oxidases; Oxidation-Reduction; Oxidoreductase; Oxygen; Oxygen Consumption; Pancreas; Pathway interactions; Phosphoric Monoester Hydrolases; Phosphotransferases; Physiological; Play; Process; Production; Property; Protein Tyrosine Kinase; Protein Tyrosine Phosphatase; Proteins; Protons; Pyruvate; Pyruvates; Quinones; Regulation; Respiration; Role; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signaling Molecule; Small Interfering RNA; Sodium; Source; Structure; Structure of beta Cell of islet; Superoxides; System; Testing; Therapeutic; Tyrosine; Tyrosine Phosphorylation; abstracting; base; cell type; design; dietary supplements; glucose metabolism; inhibitor/antagonist; insight; insulin secretion; islet; novel; novel therapeutics; oxidation; phosphatase inhibitor; reactive oxygen intermediate; response; sensor; therapeutic development; treatment response

项目成果

The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion.

• DOI: 10.1016/j.taap.2011.11.002
• 发表时间: 2012-01-15
• 期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY
• 影响因子: 3.8
• 作者: Heart, Emma;Palo, Meridith;Womack, Trayce;Smith, Peter J. S.;Gray, Joshua P.
• 通讯作者: Gray, Joshua P.