INTEGRATIVE NEUROSCIENCE INITIATIVE ON ALCOHOLISM (INIA)

关于酗酒的综合神经科学倡议 (INIA)

• 批准号: 7358784
• 负责人: DIRK MAYER
• 金额: $ 0.62万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358784
• 关键词: INTEGRATIVE; NEUROSCIENCE; INITIATIVE; ALCOHOLISM; INIA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aims: Use in vivo quantitative neuroimaging of alcohol-preferring rat (P-rat), an animal model of alcoholism, to examine longitudinal effects of alcohol exposure, while controlling for morphological changes that occur with age. Methods: Structural MRI was acquired in a longitudinal design on two cohorts of adult P-rats. Some of each cohort were never exposed to alcohol, while others received alcohol: a three-bottle choice with 0%, 15% (or 20%), and 30 % (or 40%) several different exposure schemes: continuous exposure; cycles of 2 weeks on followed by 2 weeks off alcohol; and binge drinking in the dark leading to high levels of alcohol consumption. Scanning was repeated when rats were approximately 3, 6, 10, 13, 15, and 19 months. Results: The non-alcohol exposed rats showed growth in whole brain volume that reached maximal levels by about 15 months, whereas body weight continued its gain without asymptote. Growth was not uniform across brain structures measured. Over the initial 12 months of the study, corpus callosum area expanded 36%, cerebellum 17%, and hippocampus 10%; although the ventricles enlarged 21%, the effect was not significant because of substantial between-subject variance. Factors affecting growth rate estimates included litter effects, MR image signal-to-noise ratio, and measurement error. Unlike longitudinal human reports of regional volume declines in aging brain tissue, several brain structures in adult rats continued growing. The alcohol-exposed rats also showed brain growth but this was attenuated, particularly in the corpus callosum.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目的：使用体内定量神经成像的酒精偏好大鼠（P-rat），酒精中毒的动物模型，检查酒精暴露的纵向影响，同时控制随年龄发生的形态学变化。方法：采用纵向设计，对两个队列的成年P大鼠进行结构MRI检查。每个队列中的一些人从未接触过酒精，而另一些人则接受了酒精：三瓶选择，0%，15%（或20%）和30%（或40%）几种不同的暴露方案：连续暴露; 2周的周期，然后2周的酒精;在黑暗中狂欢饮酒导致高水平的酒精消费。 当大鼠大约3、6、10、13、15和19个月时重复扫描。 结果如下：非酒精暴露的大鼠显示出全脑体积的增长，在约15个月时达到最大水平，而体重继续增加，没有渐近线。在测量的大脑结构中，生长并不均匀。在最初的12个月的研究中，胼胝体面积扩大了36%，小脑扩大了17%，海马扩大了10%;虽然脑室扩大了21%，但由于受试者之间的差异很大，这种影响并不显著。影响生长率估计的因素包括窝仔效应、MR图像信噪比和测量误差。与人类关于衰老脑组织局部体积下降的纵向报告不同，成年大鼠的几个脑结构继续生长。接触酒精的大鼠也表现出大脑生长，但这种生长被减弱，特别是在胼胝体中。