SINGLE-SHOT METABOLIC IMAGING OF THE RAT

大鼠的单次代谢成像

• 批准号: 8169893
• 负责人: DIRK MAYER
• 金额: $ 1.85万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169893
• 关键词: Chemical Shift Imaging; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Grant; Image; Institution; Metabolic; Metabolism; Nature; Performance; Pyruvate; Pyruvates; Rattus; Research; Research Personnel; Resolution; Resources; Sampling; Signal Transduction; Slice; Source; Techniques; Time; United States National Institutes of Health; Width; Work; design; in vivo; novel strategies

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hyperpolarization of metabolically active substrates such as 13C1-pyruvate permits new approaches to the investiga¿tion of in vivo metabolism using MRS and chemical shift imaging. However, the transient nature of the signal amplification necessitates fast data sampling techniques. The aim of this work was to achieve single-shot metabolic imaging in the rat in vivo by using undersampled 13C spiral CSI (spCSI) in combination with a high-performance gradient insert. The implemented sequence consists of a slice(z)-selective excitation and a spiral readout gradient for combined spatial(xy)-spectral(f) encoding. The spiral waveforms were designed for a FOV of 48¿48 mm2 with a nominal 3¿3-mm2 in-plane resolution. The insert gradients allowed a spectral width (SW) of 298 Hz in single-shot mode. With 32 echoes acquired after excitation, the total acquisition time (Tacq) was less than 120 ms.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 代谢活性底物如13 C1-丙酮酸盐的超极化允许使用MRS和化学位移成像的体内代谢的新方法。然而，信号放大的瞬态性质需要快速数据采样技术。这项工作的目的是实现单次拍摄代谢成像在大鼠体内使用欠采样13 C螺旋CSI（spCSI）结合高性能梯度插入。 所实现的序列由切片（z）选择性激励和用于组合空间（xy）-光谱（f）编码的螺旋读出梯度组成。螺旋波形设计用于48 <$48 mm 2的FOV，标称平面内分辨率为3 <$3 mm 2。插入梯度在单次激发模式下允许298 Hz的谱宽（SW）。激发后采集32个回波，总采集时间（Tacq）小于120 ms。