Long-term effects of elevated stress hormone levels in early development

应激激素水平升高对早期发育的长期影响

基本信息

  • 批准号:
    BB/D010896/1
  • 负责人:
  • 金额:
    $ 33.5万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2006
  • 资助国家:
    英国
  • 起止时间:
    2006 至 无数据
  • 项目状态:
    已结题

项目摘要

A young animal can experience stress in many ways whilst it is growing, including food shortages and high levels of disturbance from predators. The level of stress experienced at this time may itself play an important role in shaping the subsequent development of the animal such that it is either better able to maintain normal function when exposed to a stressful environment as an adult or more sensitive to stress. In this study we plan to examine the long-term effects of varying levels of stress, within the natural range. Studying the effects of stress in birds could help us answer the question of exactly how rearing conditions affect individuals when they are adults. It is difficult to measure the influence of stress in infancy on 'performance' as adults and the long-term 'performance of animals in future generations because many species are so long-lived, taking years to reach sexual maturity. In this study we plan to examine the long-term effects of varying levels of stress, within the natural range, in a relatively fast maturing bird. When an animal's environment changes unpredictably, e.g. bad weather or food shortages, they suffer stress. During this time specific chemical messengers, called stress hormones, are released into the bloodstream from the brain, pituitary and adrenal gland. In the short term these hormones can benefit the animal as they promote activities to help it survive, but if the stress continues for a long time, they can have harmful effects and can even make an animal more prone to infection. Stress can also disrupt other normal physiological systems like the reproductive system and may even stop animals breeding. Although we know a lot about how immediate stress changes an animal's behaviour, we know very little about the long-term effects of stress experienced during development on adult behaviour and an animal's ability to reproduce. Furthermore, the question of how such effects might be felt in future generations have received very little attention to date. We propose to expose young zebra finches to concentrations of the stress hormone corticosterone that would be experienced under natural conditions, in response for example to human disturbance, by feeding them very small amounts of corticosterone twice a day. It is during this time that the systems within the body that regulate a birds response to stress are developing and may be affected by exposure to high levels of stress hormones. We will then collect data on the behaviour and breeding success of these birds when they are adults. Since stress hormones also increase during breeding and breeding is known to be affected by stress we will examine whether exposure to elevated stress hormones during development will affect reproductive decision-making and have an impact on breeding success as an adult. The results of this work will provide us with information that will greatly enhance our understanding of how exposure to stress hormones early in life can program an individual response to it's environment in later life.
幼小的动物在成长过程中会经历多种压力,包括食物短缺和捕食者的高度干扰。此时所经历的压力水平本身可能在塑造动物的后续发育中发挥重要作用,从而使其在成年后暴露于压力环境时能够更好地维持正常功能,或者对压力更加敏感。在这项研究中,我们计划研究自然范围内不同压力水平的长期影响。研究压力对鸟类的影响可以帮助我们回答饲养条件究竟如何影响成年鸟类的问题。很难衡量婴儿时期的压力对成年后的“表现”以及动物后代的长期“表现”的影响,因为许多物种的寿命非常长,需要数年时间才能达到性成熟。在这项研究中,我们计划研究自然范围内不同压力水平对成熟相对较快的鸟类的长期影响。当动物的环境发生不可预测的变化时,例如恶劣的天气或食物短缺,他们会承受压力。在此期间,称为应激激素的特定化学信使从大脑、垂体和肾上腺释放到血液中。在短期内,这些激素可以使动物受益,因为它们促进活动以帮助其生存,但如果压力持续很长时间,它们可能会产生有害影响,甚至可能使动物更容易受到感染。压力还会扰乱生殖系统等其他正常生理系统,甚至可能阻止动物繁殖。尽管我们对直接压力如何改变动物的行为了解很多,但我们对发育过程中经历的压力对成年行为和动物繁殖能力的长期影响知之甚少。此外,迄今为止,关于子孙后代如何感受到这种影响的问题还很少受到关注。我们建议让幼小的斑马雀暴露在自然条件下会经历的应激激素皮质酮浓度下,例如对人类干扰的反应,通过每天两次喂食极少量的皮质酮。正是在这段时间内,调节鸟类对压力的反应的体内系统正在发育,并且可能会受到高水平应激激素的影响。然后,我们将收集这些鸟类成年后的行为和繁殖成功的数据。由于应激激素在繁殖过程中也会增加,并且已知繁殖会受到应激的影响,因此我们将研究在发育过程中暴露于升高的应激激素是否会影响繁殖决策并对成年后的繁殖成功产生影响。这项工作的结果将为我们提供信息,从而极大地增强我们对生命早期暴露于压力荷尔蒙如何影响晚年生活中的个体反应的理解。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Then versus now: effect of developmental and current environmental conditions on incubation effort in birds
过去与现在:发育和当前环境条件对鸟类孵化努力的影响
  • DOI:
    10.1093/beheco/arq090
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Spencer K
  • 通讯作者:
    Spencer K
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Pat Monaghan其他文献

Interactions between parental traits, environmental harshness and growth rate in determining telomere length in wild juvenile salmon
亲代性状、环境恶劣程度和生长速率之间的相互作用在确定野生幼鲑鱼端粒长度方面的作用
  • DOI:
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    4.9
  • 作者:
    Darryl McLennan;John D. Armstrong;D. C. Stewart;S. Mckelvey;W. Boner;Pat Monaghan;Neil B. Metcalfe
  • 通讯作者:
    Neil B. Metcalfe
Effects of vegetation on nest microclimate and breeding performance of lesser black-backed gulls (Larus fuscus)
  • DOI:
    10.1007/s10336-005-0077-6
  • 发表时间:
    2005-03-19
  • 期刊:
  • 影响因子:
    1.400
  • 作者:
    Sin-Yeon Kim;Pat Monaghan
  • 通讯作者:
    Pat Monaghan
Early life conditions reduce similarity between reproductive partners in HPA axis response to stress
早期生活条件降低了生殖伴侣之间 HPA 轴对压力反应的相似性
  • DOI:
    10.1016/j.yhbeh.2024.105508
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    B. Kriengwatana;Christopher J. Marshall;Tyler Stevenson;Pat Monaghan
  • 通讯作者:
    Pat Monaghan
Egg production constraints and the evolution of avian clutch size
产蛋限制和禽类产蛋量的演变
Out of sight but not out of harm’s way: Human disturbance reduces reproductive success of a cavity-nesting seabird
  • DOI:
    10.1016/j.biocon.2014.03.020
  • 发表时间:
    2014-06-01
  • 期刊:
  • 影响因子:
  • 作者:
    Hannah Watson;Mark Bolton;Pat Monaghan
  • 通讯作者:
    Pat Monaghan

Pat Monaghan的其他文献

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{{ truncateString('Pat Monaghan', 18)}}的其他基金

Telomeres and time: Effects of circadian rhythm disruption on telomere dynamics
端粒和时间:昼夜节律破坏对端粒动态的影响
  • 批准号:
    BB/P009174/1
  • 财政年份:
    2017
  • 资助金额:
    $ 33.5万
  • 项目类别:
    Research Grant
Early life adversity, telomere length and adult cognition: the starling as an experimental model.
早期生活的逆境、端粒长度和成年认知:八哥作为实验模型。
  • 批准号:
    BB/J015091/1
  • 财政年份:
    2012
  • 资助金额:
    $ 33.5万
  • 项目类别:
    Research Grant
Turning population ecology into conservation strategy: development of a Natural Care Scheme for red-billed choughs in Scotland
将种群生态学转化为保护战略:为苏格兰红嘴山鸦制定自然护理计划
  • 批准号:
    NE/D001161/1
  • 财政年份:
    2006
  • 资助金额:
    $ 33.5万
  • 项目类别:
    Research Grant
Life history consequences of growth variation
生长变异的生活史后果
  • 批准号:
    NE/C004353/1
  • 财政年份:
    2006
  • 资助金额:
    $ 33.5万
  • 项目类别:
    Research Grant

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