Determining modes of binding and activation of peptide G-protein coupled receptor targets

确定肽 G 蛋白偶联受体靶标的结合和激活模式

• 批准号: nhmrc : 1065481
• 负责人: A/Pr Paul Gooley
• 金额: $ 38.44万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-modes-binding-receptor-targets/455174
• 关键词: Determining; modes; binding; activation; peptide

The neuropeptide relaxin-3 and the peptide hormone INSL5 are recently discovered members of the relaxin peptide family. Relaxin-3 has important roles in stress and feeding whereas INSL5 is a gut hormone. We will study the interaction of relaxin-3 and INSL5 with their cell surface receptors and the mechanisms by which the receptors function. The knowledge gained will aid in the design of smaller, more potent and orally active forms of relaxin-3 and INSL5 for future clinical applications

神经肽松弛素-3和肽激素INSL 5是最近发现的松弛素肽家族的成员。松弛素-3在应激和进食中起重要作用，而INSL 5是一种肠道激素。我们将研究松弛素-3和INSL 5与其细胞表面受体的相互作用以及受体发挥作用的机制。所获得的知识将有助于设计更小，更有效和口服活性形式的松弛素-3和INSL 5，用于未来的临床应用