UPREGULATION OF PML IN CHLAMIDIA INFECTION

衣原体感染中 PML 的上调

• 批准号: 7365611
• 负责人: VICKIE J LAMORTE
• 金额: $ 0.19万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7365611
• 关键词: UPREGULATION; PML; CHLAMIDIA; INFECTION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chlamydia trachomatis can produce a wide range of acute clinical infections including cervicitis and salpingitis in the female; urethritis and epididymitis in the male; and conjunctivitis and pneumonia in infants. Of the estimated 4 million chlamydial infections that occur in the USA on a yearly basis, 2.6 million occur in women, 1.8 million in men, and the rest in infants. Currently, it is estimated that the incidence and prevalence of chlamydial infections in the USA are 3 and 2 million cases per year, respectively. Although in most instances C. trachomatis produces a self-limited infection, in certain individuals, the disease leads to chronic sequelae. Among the major complications tubal infertility, ectopic pregnancy and chronic abdominal pain are frequently associated with a C. trachomatis infection. In the USA, C. trachomatis infections represent the most common cause of tubal infertility. The mechanisms involved in the pathogenesis of tubal infertility resulting from a chlamydial infection are poorly understood. One possibility is that, as a result of the infection, there is fibrosis of the fallopian tube. This scar tissue will lead to the occlusion of the lumen of the fallopian tube. Alternatively, as a result of the growth of C. trachomatis, a structural and/or functional disruption of the epithelium of the fallopian tube may result in blockage of the lumen. Over the last 10 years we have implemented a murine model of C. trachomatis genital infection that closely parallels the disease in humans. Mice infected with Chlamydia develop an acute salpingitis that, over a period of 4-6 weeks, results in infertility. Using two photon imaging/spectroscopy in this model should allow us to characterize the pathogenesis of the disease and to develop diagnostic methods that may eventually be used in humans.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。沙眼衣原体可引起广泛的急性临床感染，包括女性的宫颈炎和输卵管炎;男性的尿道炎和附睾炎;以及婴儿的结膜炎和肺炎。在美国每年估计发生的400万例衣原体感染中，260万例发生在女性中，180万例发生在男性中，其余为婴儿。目前，据估计，美国衣原体感染的发病率和患病率分别为每年300万和200万例。在大多数情况下，C。沙眼产生自限性感染，在某些个体中，该疾病导致慢性后遗症。在主要并发症中，输卵管不孕、异位妊娠和慢性腹痛常与C。沙眼感染在美国，C.沙眼感染是输卵管性不孕症的最常见原因。衣原体感染导致输卵管性不孕的发病机制尚不清楚。一种可能性是，作为感染的结果，有输卵管纤维化。这种疤痕组织会导致输卵管管腔闭塞。另外，由于C.在沙眼中，输卵管上皮的结构和/或功能破坏可导致管腔堵塞。在过去的10年里，我们已经实现了一个小鼠模型的C。沙眼生殖器感染，与人类的疾病非常相似。感染衣原体的小鼠会发生急性输卵管炎，持续4-6周，导致不孕。在这个模型中使用双光子成像/光谱学应该使我们能够描述疾病的发病机制，并开发最终可能用于人类的诊断方法。