SEX DIFFERENCES IN REPOLARIZATION AND EARLY REPOLARIZATION (AIM 1)

复极和早期复极的性别差异（目标 1）

• 批准号: 7376879
• 负责人: Alan H Kadish
• 金额: $ 5.49万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376879
• 关键词: SEX; DIFFERENCES; REPOLARIZATION; EARLY; AIM

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the overall NIH grant is to investigate the characteristics and mechanisms underlying the sex differences in echocardiogram (ECG) characteristics and vulnerability to arrhythmias. The overall hypothesis is that sex differences in myocardial repolarization are both heart rate and autonomic tone dependent, are due to effects of sex hormones, and alter the propensity to clinical arrhythmias in the presence of structural heart diseases. Aim 1: Sex, repolarization and ST height: This aim will test the hypothesis that a major determinant of ST height is the level of sex hormones by examining the relationship between ST height and sex hormone levels in a mixed population without heart disease. We will also seek to determine whether exaggerated ST elevation is a continuum in normal male physiology or is a distinct clinical syndrome. In this project, we hypothesize that the level of sex hormones is a major determinant of ST height. The rationale supporting this study is that there are important sex differences in susceptibility to certain arrhtyhmias (irregular heartbeats), suggesting the existence of fundamental electrophysiologic distinctions between males and females. To test our hypothesis, we will examine the relationship between ST height and sex hormone levels in a mixed population (young and old men and women) without heart disea

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。 NIH赠款的整体目的是研究超声心动图（ECG）特征性别差异（ECG）特征和心律不齐的脆弱性的特征和机制。总体假设是，心肌重极化的性别差异既取决于心率和自主语调，这是由于性激素的影响，并且在存在结构性心脏病的情况下改变了临床心律不齐的倾向。目标1：性别，复数和ST高度：此目标将检验以下假设：ST高度的主要决定因素是性激素的水平，通过检查没有心脏病的混合种群中的ST高度与性激素水平之间的关系。我们还将寻求确定夸张的ST高程是否是正常男性生理学的连续体还是是独特的临床综合征。 在这个项目中，我们假设性激素的水平是ST高度的主要决定因素。支持这项研究的基本原理是，某些Arrhtyhmias（不规则心跳）的敏感性存在重要的性别差异，这表明男性和女性之间存在基本的电生理学差异。为了检验我们的假设，我们将研究混合人群（年轻人和老年人）没有心脏疾病的ST身高和性激素水平之间的关系