SEX DIFFERENCES IN REPOLARIZATION AND EARLY REPOLARIZATION (AIM 1)

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。美国国立卫生研究院总体拨款的目的是调查超声心动图（ECG）特征和心律失常易感性的性别差异的特征和机制。总的假设是，心肌复极的性别差异依赖于心率和自主神经张力，是由于性激素的影响，并且在存在结构性心脏病的情况下改变临床心律失常的倾向。目的1：性别、复极和ST高度：该目的将通过检查无心脏病的混合人群中ST高度和性激素水平之间的关系来检验ST高度的主要决定因素是性激素水平的假设。我们还将试图确定ST段抬高是否在正常男性生理中是连续的，还是一种独特的临床综合征。在这个项目中，我们假设性激素水平是ST高度的主要决定因素。支持这项研究的基本原理是，对某些心律失常（心律不齐）的易感性存在重要的性别差异，这表明男性和女性之间存在基本的电生理差异。为了验证我们的假设，我们将在没有心脏病的混合人群（年轻和老年男性和女性）中检查ST段高度和性激素水平之间的关系

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the overall NIH grant is to investigate the characteristics and mechanisms underlying the sex differences in echocardiogram (ECG) characteristics and vulnerability to arrhythmias. The overall hypothesis is that sex differences in myocardial repolarization are both heart rate and autonomic tone dependent, are due to effects of sex hormones, and alter the propensity to clinical arrhythmias in the presence of structural heart diseases. Aim 1: Sex, repolarization and ST height: This aim will test the hypothesis that a major determinant of ST height is the level of sex hormones by examining the relationship between ST height and sex hormone levels in a mixed population without heart disease. We will also seek to determine whether exaggerated ST elevation is a continuum in normal male physiology or is a distinct clinical syndrome. In this project, we hypothesize that the level of sex hormones is a major determinant of ST height. The rationale supporting this study is that there are important sex differences in susceptibility to certain arrhtyhmias (irregular heartbeats), suggesting the existence of fundamental electrophysiologic distinctions between males and females. To test our hypothesis, we will examine the relationship between ST height and sex hormone levels in a mixed population (young and old men and women) without heart disea