SEX DIFFERENCES IN REPOLARIZATION AND EARLY REPOLARIZATION - AIM 3

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在这个项目中，我们假设性激素水平是心肌复极（ST段高度）的主要决定因素。 支持这项研究的基本原理是，在某些心律失常（不规则心跳）的易感性方面存在重要的性别差异，表明男性和女性之间存在基本的电生理差异。 为了验证我们的假设，我们将在接受激素替代治疗的无心脏病受试者（年轻和老年男性和女性）以及未接受激素替代治疗的受试者的混合人群中检查ST高度和性激素水平之间的关系。 具体而言，将对受试者进行超声心动图检查（一种使用声波的测试，可以勾勒出心脏的大小，并确定心脏的功能如何），被要求在固定自行车上做运动测试（其记录受试者踩踏板时的心脏电活动），如果女性月经周期规律，尿排卵预测测试，并给予20毫升的血液，以确定几个性激素水平。 我们将寻求确定ST变量的变化幅度，根据激素水平的变化发生在正常月经周期的不同阶段，并在长期性激素治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project, we hypothesize that the level of sex hormones is a major determinant of myocardial repolarization (ST height). The rationale supporting this study is that there are important sex differences in susceptibility to certain arrhtyhmias (irregular heartbeats), suggesting the existence of fundamental electrophysiologic distinctions between males and females. To test our hypothesis, we will examine the relationship between ST height and sex hormone levels in a mixed population of subjects (young and old men and women) without heart disease undergoing hormonal replacement therapy and in subjects not undergoing hormal replacement therapy. Specifically, subjects will be given an echocardiogram (a test using a sound wave that outlines the size of the heart and determines how well the heart is functioning), asked to do an exercise test on a stationary bicycle (which records the heart's electrical activity while the subject is pedaling), undergo, if females with regular menstrual cycles, a urinary ovulation predictor test and give 20ccs of blood to determine several sex hormone levels. We will seek to determine the magnitude of changes in ST variables according to hormone levels changes occuring during the different phases of a normal menstrual cycle and following a long-term sex hormones therapy.