SEX DIFFERENCES IN REPOLARIZATION AND EARLY REPOLARIZATION - AIM 1

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 总体NIH资助的目的是研究超声心动图（ECG）特征和心律失常易感性性别差异的特征和机制。 总的假设是，性别差异心肌复极的心率和自主神经张力依赖，是由于性激素的影响，并改变临床心律失常的结构性心脏病的存在的倾向。 目标1：性别、复极和ST段高度：这一目的将通过检查无心脏病的混合人群中ST段高度和性激素水平之间的关系，检验ST段高度的主要决定因素是性激素水平的假设。 我们还将试图确定是否夸大ST段抬高是一个连续的正常男性生理或一个独特的临床综合征。 在这个项目中，我们假设性激素水平是ST段高度的主要决定因素。 支持这项研究的基本原理是，在某些心律失常（不规则心跳）的易感性方面存在重要的性别差异，表明男性和女性之间存在基本的电生理差异。 为了验证我们的假设，我们将在一个没有心脏病的混合人群（年轻和老年男性和女性）中研究ST段高度和性激素水平之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the overall NIH grant is to investigate the characteristics and mechanisms underlying the sex differences in echocardiogram (ECG) characteristics and vulnerability to arrhythmias. The overall hypothesis is that sex differences in myocardial repolarization are both heart rate and autonomic tone dependent, are due to effects of sex hormones, and alter the propensity to clinical arrhythmias in the presence of structural heart diseases. Aim 1: Sex, repolarization and ST height: This aim will test the hypothesis that a major determinant of ST height is the level of sex hormones by examining the relationship between ST height and sex hormone levels in a mixed population without heart disease. We will also seek to determine whether exaggerated ST elevation is a continuum in normal male physiology or is a distinct clinical syndrome. In this project, we hypothesize that the level of sex hormones is a major determinant of ST height. The rationale supporting this study is that there are important sex differences in susceptibility to certain arrhtyhmias (irregular heartbeats), suggesting the existence of fundamental electrophysiologic distinctions between males and females. To test our hypothesis, we will examine the relationship between ST height and sex hormone levels in a mixed population (young and old men and women) without heart disease.