SEX DIFFERENCES IN REPOLARIZATION AND EARLY REPOLARIZATION - AIM 1

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 NIH的全部拨款的目的是调查超声心动图(ECG)特征和易患心律失常的性别差异的特征和机制。总体假设是，心肌复极的性别差异既依赖心率又依赖自主神经张力，是由于性激素的影响，并在存在结构性心脏病时改变临床心律失常的倾向。 目的1：性别、复极和ST高度：这个目的将通过研究ST高度和性激素水平之间的关系来检验ST高度的主要决定因素是性激素水平这一假说。我们还将试图确定ST段抬高过高是正常男性生理中的一种连续体，还是一种独特的临床综合征。 在这个项目中，我们假设性激素水平是ST高度的主要决定因素。支持这项研究的理论基础是，在某些心律失常(不规则心跳)的易感性方面存在重要的性别差异，这表明男性和女性之间存在基本的电生理差异。为了验证我们的假设，我们将检验没有心脏病的混合人群(年轻的、老年的男性和女性)ST高度和性激素水平之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the overall NIH grant is to investigate the characteristics and mechanisms underlying the sex differences in echocardiogram (ECG) characteristics and vulnerability to arrhythmias. The overall hypothesis is that sex differences in myocardial repolarization are both heart rate and autonomic tone dependent, are due to effects of sex hormones, and alter the propensity to clinical arrhythmias in the presence of structural heart diseases. Aim 1: Sex, repolarization and ST height: This aim will test the hypothesis that a major determinant of ST height is the level of sex hormones by examining the relationship between ST height and sex hormone levels in a mixed population without heart disease. We will also seek to determine whether exaggerated ST elevation is a continuum in normal male physiology or is a distinct clinical syndrome. In this project, we hypothesize that the level of sex hormones is a major determinant of ST height. The rationale supporting this study is that there are important sex differences in susceptibility to certain arrhtyhmias (irregular heartbeats), suggesting the existence of fundamental electrophysiologic distinctions between males and females. To test our hypothesis, we will examine the relationship between ST height and sex hormone levels in a mixed population (young and old men and women) without heart disease.