SEX DIFFERENCES IN EARLY MYOCARDIAL REPOLARIZATION (AIM 4)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究旨在探讨心电特征与心律失常易感性性别差异的特点及机制。本研究的总体假设是，心肌复极的性别差异既依赖心率，又依赖自主神经张力，是由于性激素的影响，并在存在结构性心脏病的情况下改变临床心律失常的倾向。目的4d：本研究的目的是在电生理测试中检验有无诱发性室性心动过速患者的ST段高度和其他复极变量是否存在差异，并解释VT诱发性的性别差异。这项人群研究将确定早期心肌复极差异的潜在临床效应和预测价值(IRB#0278-033)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate the characteristics and mechanisms underlying the sex differences in ECG characteristics and vulnerability to arrhythmias. The overall hypothesis of the present study is that sex differences in myocardial repolarization are both heart rate and autonomic tone dependent, are due to effects of sex hormones and alter the propensity to clinical arrhythmias in the presence of structural heart diseases. Aim 4d: This specific aim will test if there is a difference in the ST height and other repolarization variables between subjects with and without inducible ventricular tachycardia at electrophysiologic testing and can this explain the sex difference in VT inducibility. This population study will determine potential clinical effects - and predictive value - of differences in early myocardial repolarization (IRB# 0278-033).