SEX DIFFERENCES IN EARLY MYOCARDIAL REPOLARIZATION (AIM 4)

早期心肌复极的性别差异（目标 4）

• 批准号: 7376887
• 负责人: Alan H Kadish
• 金额: $ 0.25万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376887
• 关键词: SEX; DIFFERENCES; EARLY; MYOCARDIAL; REPOLARIZATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate the characteristics and mechanisms underlying the sex differences in ECG characteristics and vulnerability to arrhythmias. The overall hypothesis of the present study is that sex differences in myocardial repolarization are both heart rate and autonomic tone dependent, are due to effects of sex hormones and alter the propensity to clinical arrhythmias in the presence of structural heart diseases. Aim 4d: This specific aim will test if there is a difference in the ST height and other repolarization variables between subjects with and without inducible ventricular tachycardia at electrophysiologic testing and can this explain the sex difference in VT inducibility. This population study will determine potential clinical effects - and predictive value - of differences in early myocardial repolarization (IRB# 0278-033).

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究的目的是探讨心电图特征和心律失常易感性的性别差异的特点和机制。本研究的总体假设是，心肌复极的性别差异是心率和自主神经张力依赖性的，是由于性激素的影响，并改变结构性心脏病存在的临床心律失常的倾向。 目标4d：这一特定目的将测试在电生理测试中有和没有诱导室性心动过速的受试者之间ST段高度和其他复极变量是否存在差异，这是否可以解释诱导室性心动过速的性别差异。这项人群研究将确定早期心肌复极差异的潜在临床效应和预测价值（IRB# 0278-033）。