Procedures to Assess the Hazards of a Superfund Site

描述(由申请人提供) 德克萨斯农工大学拟议的SBRP将利用综合研究模型来调查超级基金化学品和混合物对生态和人类健康的潜在不利影响，以改进风险评估范式。该计划的主要目标是进行基础研究，以减少与复杂混合物风险评估相关的不确定性，并提高科学和公众对整个风险评估过程的信心。申请人假设，接触与超级基金有关的化学品混合物对环境和人类健康造成的不利影响是多因素的，并与个别化学品及其处置的相互作用以及目标生物受体及其遗传敏感性的接触有关。拟议的研究包括三个基于机制的研究项目，重点是超级基金毒物，这些毒物通过内分泌干扰、遗传毒性和细胞损伤发挥作用。项目4将调查化学导致的出生缺陷的遗传易感性和易感性。项目5将开发修复受污染介质的新方法。项目6将调查人类和生态系统暴露和风险评估研究。项目7将调查影响出生缺陷风险的基因-环境相互作用。这七个单独项目的研究将得到图像分析、分析、实地研究、行政和培训核心的支持。该计划还包括一个研究翻译核心，该核心将扩大与美国环境保护局(USEPA)区域地点经理的持续合作，以促进将生物测试方案纳入超级基金地点的风险评估。外展核心将向社区团体和学生传达研究结果。

DESCRIPTION (provide by applicant) The proposed SBRP at Texas A&M University will utilize an integrated research model to investigate the potential adverse ecological and human health effects of Superfund chemicals and mixtures to improve the risk assessment paradigm. The major objective of the Program is to conduct fundamental research to reduce the uncertainty associated with risk assessment of complex mixtures, and to improve scientific and public confidence in the overall risk assessment process. The applicants hypothesize that adverse environmental and human health effects resulting from exposure to Superfund-related chemical mixtures are multi-factorial and associated with interactions of individual chemicals and their disposition, as well as exposure of target biological receptors and their genetic sensitivities. The proposed studies include three mechanism-based research projects focused on Superfund toxicants that act through endocrine disruption, genotoxicity and cellular injury. Project 4 will investigate genetic susceptibility and predisposition to chemical-induced birth defects. The development of novel methods for remediation of contaminated media will be carried out in Project 5. Human and ecosystem exposure and risk assessment studies will be investigated in Project 6. Project 7 will investigate gene-environment interactions affecting the risk of birth defects. Research in the seven individual projects will be supported by the Image Analysis, Analytical, Field Studies, Administrative, and Training Cores. The Program also includes a Research Translation Core that will expand ongoing collaborations with Regional Site Managers at the United States Environmental Protection Agency (USEPA) to facilitate incorporation of biological test protocols into risk assessment at Superfund sites. An Outreach Core will communicate research results to community groups and students.