Harnessing the type VI secretion system ‘combat’ arsenal of A. baumannii as a source of new antimicrobials and antimicrobial targets

利用鲍曼不动杆菌的 VI 型分泌系统“战斗”武器库作为新抗菌药物和抗菌靶点的来源

• 批准号: nhmrc : 1128981
• 负责人: A/Pr John Boyce
• 金额: $ 35.61万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/harnessing-type-vi-antimicrobial-targets/948325
• 关键词: Harnessing; type; VI; secretion; system

Infections caused by drug-resistant bacteria represent one of the greatest threats to human health. There is an urgent need to develop novel drugs and treatment strategies to combat infections by these drug-resistant organisms. We have shown that the bacteria A. baumannii uses a needle-like system to deliver lethal toxins into competitors. We will characterize these toxins so that we can manipulate them as weapons for controlling infections with multi-drug resistant bacteria.

由耐药细菌引起的感染是对人类健康的最大威胁之一。迫切需要开发新的药物和治疗策略来对抗这些耐药生物体的感染。我们已经证明，细菌A.鲍曼不动杆菌使用针状系统将致命毒素输送到竞争对手体内。我们将描述这些毒素的特征，以便我们可以操纵它们作为控制多重耐药细菌感染的武器。