Targeting NDM-producing ‘superbugs’: optimising novel combinations with ‘old’ polymyxins using pharmacological, molecular imaging and systems biology approaches

针对产生 NDM 的“超级细菌”：利用药理学、分子成像和系统生物学方法优化与“旧”多粘菌素的新型组合

• 批准号: nhmrc : 1046561
• 负责人: A/Pr John Boyce
• 金额: $ 38.86万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-ndm-producing-biology-approaches/111850
• 关键词: Targeting; NDM; producing; superbugs; optimising

Rapid global spread of so-called NDM-producing bacterial ‘superbugs’ is presenting a major medical challenge. Without new antibiotics under development, polymyxin is becoming the only effective antibiotic. Unfortunately we recently revealed that treatment with polymyxin alone can rapidly lead to resistance in NDM-producing ‘superbugs’. This project will employ new tools to optimise rational polymyxin combinations, thereby providing urgently needed information to clinicians for treating these very problematic infections.

所谓的NDM生产细菌“超级细菌”的快速全球传播正在提出一个重大的医学挑战。在没有新抗生素开发的情况下，多粘菌素正在成为唯一有效的抗生素。不幸的是，我们最近发现，单独使用多粘菌素治疗可以迅速导致产生NDM的“超级细菌”产生耐药性。该项目将采用新的工具来优化合理的多粘菌素组合，从而为临床医生治疗这些非常有问题的感染提供急需的信息。