Targeting NDM-producing ‘superbugs’: optimising novel combinations with ‘old’ polymyxins using pharmacological, molecular imaging and systems biology approaches

所谓的NDM生产细菌“超级细菌”的快速全球传播正在提出一个重大的医学挑战。在没有新抗生素开发的情况下，多粘菌素正在成为唯一有效的抗生素。不幸的是，我们最近发现，单独使用多粘菌素治疗可以迅速导致产生NDM的“超级细菌”产生耐药性。该项目将采用新的工具来优化合理的多粘菌素组合，从而为临床医生治疗这些非常有问题的感染提供急需的信息。

Rapid global spread of so-called NDM-producing bacterial ‘superbugs’ is presenting a major medical challenge. Without new antibiotics under development, polymyxin is becoming the only effective antibiotic. Unfortunately we recently revealed that treatment with polymyxin alone can rapidly lead to resistance in NDM-producing ‘superbugs’. This project will employ new tools to optimise rational polymyxin combinations, thereby providing urgently needed information to clinicians for treating these very problematic infections.